ENSMUSG00000051920


Mus musculus

Features
Gene ID: ENSMUSG00000051920
  
Biological name :Rspo2
  
Synonyms : Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q8BFU0 / Rspo2
  
Possible biological names infered from orthology : Q6UXX9 / R-spondin 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.2
Gene start: 43020794
Gene end: 43170826
  
Corresponding Affymetrix probe sets: 10428388 (MoGene1.0st)   1430104_at (Mouse Genome 430 2.0 Array)   1455893_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067325
Ensembl peptide - ENSMUSP00000154600
NCBI entrez gene - 239405     See in Manteia.
MGI - MGI:1922667
RefSeq - XM_017316596
RefSeq - NM_001357956
RefSeq - NM_001357957
RefSeq - NM_172815
RefSeq - XM_006520905
RefSeq - XM_011245607
RefSeq - XM_011245608
RefSeq - XM_011245609
RefSeq Peptide - NP_001344886
RefSeq Peptide - NP_766403
RefSeq Peptide - NP_001344885
swissprot - Q8BFU0
Ensembl - ENSMUSG00000051920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rspo2ENSDARG00000079570Danio rerio
 RSPO2ENSGALG00000030030Gallus gallus
 RSPO2ENSG00000147655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rspo3 / Q2TJ95 / R-spondin-3 / Q9BXY4*ENSMUSG0000001988043
Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*ENSMUSG0000003285240
Rspo1 / R-spondin 1 / Q2MKA7*ENSMUSG0000002887139


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030282 bone mineralization IGI
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0042489 negative regulation of odontogenesis of dentin-containing tooth IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060437 lung growth IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 biological_processGO:0060535 trachea cartilage morphogenesis IGI
 biological_processGO:0071542 dopaminergic neuron differentiation IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm3.1Grid/Notch2+
Genetic Background: B6.129S1-Jag1tm1Grid Notch2tm3.1Grid

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: BALB/cA * C57BL/6 * DBA/1

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0000553 absent radius "missing the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: BALB/cA * C57BL/6 * DBA/1

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Nuv/Rspo2+
Genetic Background: involves: 129 * C57BL/6

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0002256 abnormal laryngeal cartilage morphology "any structural anomaly of the cartilagenous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0002257 abnormal arytenoid cartilage morphology "any structural anomaly of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0002258 abnormal cricoid cartilage morphology "any structural anomaly of the most inferior of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002728 absent tibia "missing the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0003604 single kidney 
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2ftls/Rspo2+
Genetic Background: involves: FVB/N

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0004540 small maxilla "reduced size of the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0004912 absent mandibular coronoid process "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005359 growth retardation of incisors "developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Rspo2ftls/Rspo2ftls
Genetic Background: Not Specified

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0008494 absence of all nails "absence of all of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2ftls/Rspo2+
Genetic Background: involves: FVB/N

Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0009895 decreased palatine shelf size "reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0009898 maxillary shelf hypoplasia "underdevelopment, usually due to a deficiency in the number of cells, of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rspo2tm1Suda/Rspo2tm1Suda
Genetic Background: B6.Cg-Rspo2tm1Suda

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Agatm1Vk/Agatm1Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rspo2tm1Hoka/Rspo2tm1Hoka
Genetic Background: involves: C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011262 abnormal branchial arch mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0013933 short Meckel s cartilage 
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+,Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

 MP:0030302 abnormal maxillary zygomatic process morphology "any structural anomaly of the rough triangular eminence situated at the angle of separation of the anterior, zygomatic, and orbital surfaces; in front, it forms part of the anterior surface; behind, it is concave, and forms part of the infratemporal fossa; above, it is rough and serrated for articulation with the zygomatic bone; below, it presents the prominent arched border which marks the division between the anterior and infratemporal surfaces" [https://en.wikipedia.org/wiki/Zygomatic_process_of_maxilla]
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Allelic Composition: Rspo2tm1Nuv/Rspo2tm1Nuv
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034177 Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*  / reaction / complex
 ENSMUSG00000050199 Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*  / reaction / complex
 ENSMUSG00000020140 Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*  / complex / reaction
 ENSMUSG00000042793 Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*  / complex / reaction
 ENSMUSG00000041961 Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*  / complex / reaction






 

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