ENSG00000147655


Homo sapiens

Features
Gene ID: ENSG00000147655
  
Biological name :RSPO2
  
Synonyms : Q6UXX9 / RSPO2 / R-spondin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q23.1
Gene start: 107899316
Gene end: 108083648
  
Corresponding Affymetrix probe sets: 1554012_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427937
Ensembl peptide - ENSP00000430973
Ensembl peptide - ENSP00000430485
Ensembl peptide - ENSP00000430010
Ensembl peptide - ENSP00000429159
Ensembl peptide - ENSP00000428940
Ensembl peptide - ENSP00000428614
Ensembl peptide - ENSP00000276659
NCBI entrez gene - 340419     See in Manteia.
OMIM - 610575
RefSeq - XM_017013395
RefSeq - NM_001282863
RefSeq - NM_001317942
RefSeq - NM_178565
RefSeq - XM_011517018
RefSeq - XM_011517019
RefSeq Peptide - NP_001269792
RefSeq Peptide - NP_001304871
RefSeq Peptide - NP_848660
swissprot - E5RH25
swissprot - E5RGU9
swissprot - E5RJA2
swissprot - E5RHC3
swissprot - E5RJU7
swissprot - Q6UXX9
Ensembl - ENSG00000147655
  
Related genetic diseases (OMIM): 618021 - Tetraamelia syndrome 2, 618021
  618022 - ?Humerofemoral hypoplasia with radiotibial ray deficiency, 618022
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rspo2ENSDARG00000079570Danio rerio
 RSPO2ENSGALG00000030030Gallus gallus
 Rspo2ENSMUSG00000051920Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RSPO3 / Q9BXY4 / R-spondin 3ENSG0000014637445
RSPO1 / Q2MKA7 / R-spondin 1ENSG0000016921840
RSPO4 / Q2I0M5 / R-spondin 4ENSG0000010128235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway NAS
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0042489 negative regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060437 lung growth IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060535 trachea cartilage morphogenesis IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139292 LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5  / complex / reaction
 ENSG00000133067 LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6  / reaction / complex
 ENSG00000108375 RNF43 / Q68DV7 / ring finger protein 43  / reaction / complex
 ENSG00000183579 ZNRF3 / Q9ULT6 / zinc and ring finger 3  / complex / reaction
 ENSG00000205213 LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4  / reaction / complex






 

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