ENSG00000133067


Homo sapiens

Features
Gene ID: ENSG00000133067
  
Biological name :LGR6
  
Synonyms : leucine rich repeat containing G protein-coupled receptor 6 / LGR6 / Q9HBX8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 202193901
Gene end: 202319781
  
Corresponding Affymetrix probe sets: 227819_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000255432
Ensembl peptide - ENSP00000387869
Ensembl peptide - ENSP00000402284
Ensembl peptide - ENSP00000422143
Ensembl peptide - ENSP00000356247
NCBI entrez gene - 59352     See in Manteia.
OMIM - 606653
RefSeq - XM_017001997
RefSeq - NM_001017403
RefSeq - NM_001017404
RefSeq - NM_021636
RefSeq - XM_011509841
RefSeq - XM_011509842
RefSeq - XM_011509843
RefSeq - XM_011509844
RefSeq - XM_011509846
RefSeq - XM_017001996
RefSeq - XM_005245404
RefSeq - XM_011509838
RefSeq - XM_011509839
RefSeq - XM_011509840
RefSeq Peptide - NP_001017403
RefSeq Peptide - NP_001017404
RefSeq Peptide - NP_067649
swissprot - Q5T508
swissprot - Q9HBX8
swissprot - D6R9F0
Ensembl - ENSG00000133067
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGR6ENSGALG00000000568Gallus gallus
 Lgr6ENSMUSG00000042793Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5ENSG0000013929251
LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4ENSG0000020521345
FSHR / P23945 / follicle stimulating hormone receptorENSG0000017082018
TSHR / P16473 / thyroid stimulating hormone receptorENSG0000016540918
LHCGR / P22888 / luteinizing hormone/choriogonadotropin receptorENSG0000013803917
RXFP1 / Q9HBX9 / relaxin/insulin like family peptide receptor 1ENSG0000017150915
RXFP2 / Q8WXD0 / relaxin/insulin like family peptide receptor 2ENSG0000013310515
AC073082.1ENSG000002799566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 biological_processGO:1990523 bone regeneration IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032588 trans-Golgi network membrane ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169218 RSPO1 / Q2MKA7 / R-spondin 1  / complex / reaction
 ENSG00000108375 RNF43 / Q68DV7 / ring finger protein 43  / reaction / complex
 ENSG00000146374 RSPO3 / Q9BXY4 / R-spondin 3  / reaction / complex
 ENSG00000101282 RSPO4 / Q2I0M5 / R-spondin 4  / reaction / complex
 ENSG00000183579 ZNRF3 / Q9ULT6 / zinc and ring finger 3  / reaction / complex
 ENSG00000147655 RSPO2 / Q6UXX9 / R-spondin 2  / reaction / complex






 

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