ENSMUSG00000042793


Mus musculus

Features
Gene ID: ENSMUSG00000042793
  
Biological name :Lgr6
  
Synonyms : Leucine-rich repeat-containing G-protein coupled receptor 6 / Lgr6 / Q3UVD5
  
Possible biological names infered from orthology : Q9HBX8
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 134983301
Gene end: 135105276
  
Corresponding Affymetrix probe sets: 10357965 (MoGene1.0st)   1427028_at (Mouse Genome 430 2.0 Array)   1436218_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035444
Ensembl peptide - ENSMUSP00000122334
NCBI entrez gene - 329252     See in Manteia.
MGI - MGI:2441805
RefSeq - XM_017321280
RefSeq - NM_001033409
RefSeq - XM_006529714
RefSeq - XM_011248036
RefSeq Peptide - NP_001028581
swissprot - D3Z6S4
swissprot - Q3UVD5
Ensembl - ENSMUSG00000042793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGR6ENSGALG00000000568Gallus gallus
 LGR6ENSG00000133067Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*ENSMUSG0000002014051
Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*ENSMUSG0000005019944
Fshr / P35378 / Follicle-stimulating hormone receptor / P23945*ENSMUSG0000003293718
Tshr / P47750 / thyroid stimulating hormone receptor / P16473*ENSMUSG0000002096318
Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*ENSMUSG0000002410717
Rxfp2 / Q91ZZ5 / Relaxin receptor 2 / Q8WXD0* / relaxin/insulin like family peptide receptor 2*ENSMUSG0000005336816
Rxfp1 / Q6R6I7 / Relaxin receptor 1 / Q9HBX9* / relaxin/insulin like family peptide receptor 1*ENSMUSG0000003400915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042246 tissue regeneration IMP
 biological_processGO:1990523 bone regeneration IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Lgr6tm2.1(cre/ERT2)Cle/Lgr6tm2.1(cre/ERT2)Cle
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028871 Rspo1 / R-spondin 1 / Q2MKA7*  / reaction / complex
 ENSMUSG00000032852 Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*  / complex / reaction
 ENSMUSG00000034177 Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*  / reaction / complex
 ENSMUSG00000041961 Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*  / complex / reaction
 ENSMUSG00000051920 Rspo2 / Q8BFU0 / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q6UXX9* / R-spondin 2*  / complex / reaction
 ENSMUSG00000019880 Rspo3 / Q2TJ95 / R-spondin-3 / Q9BXY4*  / complex / reaction






 

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