ENSMUSG00000028871


Mus musculus

Features
Gene ID: ENSMUSG00000028871
  
Biological name :Rspo1
  
Synonyms : Rspo1 / R-spondin 1
  
Possible biological names infered from orthology : Q2MKA7
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 124986430
Gene end: 125009099
  
Corresponding Affymetrix probe sets: 10508012 (MoGene1.0st)   1449319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030687
NCBI entrez gene - 192199     See in Manteia.
MGI - MGI:2183426
RefSeq - NM_138683
RefSeq - XM_006502862
RefSeq Peptide - NP_619624
swissprot - B1ASC1
Ensembl - ENSMUSG00000028871
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rspo1ENSDARG00000104340Danio rerio
 RSPO1ENSGALG00000001946Gallus gallus
 RSPO1ENSG00000169218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rspo3 / Q2TJ95 / R-spondin-3 / Q9BXY4*ENSMUSG0000001988043
Rspo2 / Q8BFU0 / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q6UXX9* / R-spondin 2*ENSMUSG0000005192035
Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*ENSMUSG0000003285229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002090 regulation of receptor internalization IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0002783 abnormal ovarian secretion "malfunction of the production and/or release of hormones from ovarian tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002787 pseudohermaphroditism "unambiguous gonadal sex (i.e. possesses either testes or ovaries, consistent with chromosomal sex) but has ambiguous secondary sexual characteristics" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129 * C57BL/6J

 MP:0003582 abnormal ovary development "abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129 * C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129 * C57BL/6J

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129 * C57BL/6J

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
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Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020140 Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*  / reaction / complex
 ENSMUSG00000042793 Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*  / complex / reaction
 ENSMUSG00000050199 Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*  / complex / reaction
 ENSMUSG00000034177 Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*  / complex / reaction
 ENSMUSG00000041961 Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*  / complex / reaction






 

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