ENSDARG00000104340


Danio rerio

Features
Gene ID: ENSDARG00000104340
  
Biological name :rspo1
  
Synonyms : Q6DHR0 / rspo1 / R-spondin 1
  
Possible biological names infered from orthology : Q2MKA7
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 33772902
Gene end: 33817828
  
Corresponding Affymetrix probe sets: Dr.11481.1.A1_at (Zebrafish Array)   NM_001002352_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135809
Ensembl peptide - ENSDARP00000149963
Ensembl peptide - ENSDARP00000151422
NCBI entrez gene - 436625     See in Manteia.
RefSeq - NM_001002352
RefSeq Peptide - NP_001002352
swissprot - M5AP50
swissprot - Q6DHR0
ZFIN ID - ZDB-GENE-040718-44
Ensembl - ENSDARG00000104340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RSPO1ENSGALG00000001946Gallus gallus
 RSPO1ENSG00000169218Homo sapiens
 Rspo1ENSMUSG00000028871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rspo3 / R-spondin 3 / Q2TJ95* / Q9BXY4*ENSDARG0000007008138
rspo2 / R-spondin 2 / Q6UXX9* / Q8BFU0* / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA.*ENSDARG0000007957036
rspo4 / R-spondin 4 / Q2I0M5* / Q8BJ73*ENSDARG0000003859331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000106 extension extension decreased width , abnormal
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 ZFA:0001115 trunk trunk endothelial cell decreased amount , abnormal
trunk lymph vasculature absent , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel absent , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel decreased amount , abnormal
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 ZFA:0005021 cerebellar central artery cerebellar central artery absent , abnormal
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 ZFA:0005052 anterior mesencephalic central artery anterior mesencephalic central artery absent , abnormal
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 ZFA:0005078 middle mesencephalic central artery middle mesencephalic central artery absent , abnormal
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 ZFA:0005079 posterior mesencephalic central artery posterior mesencephalic central artery absent , abnormal
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 ZFA:0005559 vascular sprouts vascular sprouts filopodium absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000060542 lgr4 / E7FE13 / leucine-rich repeat containing G protein-coupled receptor 4 / A2ARI4* / Q9BXB1*  / complex / reaction






 

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