ENSMUSG00000019880


Mus musculus

Features
Gene ID: ENSMUSG00000019880
  
Biological name :Rspo3
  
Synonyms : Q2TJ95 / Rspo3 / R-spondin-3
  
Possible biological names infered from orthology : Q9BXY4
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A4
Gene start: 29452416
Gene end: 29535867
  
Corresponding Affymetrix probe sets: 10368495 (MoGene1.0st)   1443187_at (Mouse Genome 430 2.0 Array)   1455607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149363
Ensembl peptide - ENSMUSP00000090287
NCBI entrez gene - 72780     See in Manteia.
MGI - MGI:1920030
RefSeq - NM_028351
RefSeq Peptide - NP_082627
swissprot - A0A1L1SR88
swissprot - Q2TJ95
Ensembl - ENSMUSG00000019880
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rspo3ENSDARG00000070081Danio rerio
 RSPO3ENSGALG00000042607Gallus gallus
 RSPO3ENSG00000146374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rspo1 / R-spondin 1 / Q2MKA7*ENSMUSG0000002887141
Rspo2 / Q8BFU0 / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q6UXX9* / R-spondin 2*ENSMUSG0000005192038
Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*ENSMUSG0000003285229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0001711 abnormal placenta 
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Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Nkx2-5tm1Krc/Nkx2-5tm1Krc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc2tm1.2Tsku/Foxc2tm1.2Tsku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

 MP:0002728 absent tibia "missing the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0003649 reduced right ventricle 
Show

Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rspo2ftls/Rspo2ftls,Rspo3tm1.1Jcob/Rspo3tm1.2Jcob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rspo3tm1.2Jcob/Rspo3tm1.2Jcob
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034177 Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*  / complex / reaction
 ENSMUSG00000050199 Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*  / reaction / complex
 ENSMUSG00000020140 Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*  / complex / reaction
 ENSMUSG00000042793 Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*  / reaction / complex
 ENSMUSG00000041961 Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*  / complex / reaction






 

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