Manteia - Molecule gene

ENSMUSG00000050199

Mus musculus

Features

Gene ID:	ENSMUSG00000050199

Biological name :	Lgr4

Synonyms :	A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Lgr4

Possible biological names infered from orthology :	Q9BXB1

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	E3
Gene start:	109917647
Gene end:	110014257

Corresponding Affymetrix probe sets:	10474419 (MoGene1.0st) 1433891_at (Mouse Genome 430 2.0 Array) 1453765_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000106666 Ensembl peptide - ENSMUSP00000047325 NCBI entrez gene - 107515 See in Manteia. MGI - MGI:1891468 RefSeq - NM_172671 RefSeq Peptide - NP_766259 swissprot - A2ARI4 Ensembl - ENSMUSG00000050199

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lgr4	ENSDARG00000060542	Danio rerio
LGR4	ENSGALG00000040834	Gallus gallus
LGR4	ENSG00000205213	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*	ENSMUSG00000042793	45
Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*	ENSMUSG00000020140	45
Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*	ENSMUSG00000024107	17
Tshr / P47750 / thyroid stimulating hormone receptor / P16473*	ENSMUSG00000020963	17
Fshr / P35378 / Follicle-stimulating hormone receptor / P23945*	ENSMUSG00000032937	17
Rxfp2 / Q91ZZ5 / Relaxin receptor 2 / Q8WXD0* / relaxin/insulin like family peptide receptor 2*	ENSMUSG00000053368	15
Rxfp1 / Q6R6I7 / Relaxin receptor 1 / Q9HBX9* / relaxin/insulin like family peptide receptor 1*	ENSMUSG00000034009	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR000372	Leucine-rich repeat N-terminal domain
IPR001611	Leucine-rich repeat
IPR002131	Glycoprotein hormone receptor family
IPR003591	Leucine-rich repeat, typical subtype
IPR017452	GPCR, rhodopsin-like, 7TM
IPR032675	Leucine-rich repeat domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001649	osteoblast differentiation	IMP
biological_process	GO:0001942	hair follicle development	IMP
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0007623	circadian rhythm	IEP
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030282	bone mineralization	IMP
biological_process	GO:0030539	male genitalia development	IMP
biological_process	GO:0032922	circadian regulation of gene expression	IMP
biological_process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP
biological_process	GO:0035239	tube morphogenesis	IMP
biological_process	GO:0036335	intestinal stem cell homeostasis	IMP
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
biological_process	GO:0046849	bone remodeling	IMP
biological_process	GO:0048511	rhythmic process	IEA
biological_process	GO:0048565	digestive tract development	IMP
biological_process	GO:0050673	epithelial cell proliferation	IMP
biological_process	GO:0050710	negative regulation of cytokine secretion	IMP
biological_process	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	IMP
biological_process	GO:0072202	cell differentiation involved in metanephros development	IMP
biological_process	GO:0072224	metanephric glomerulus development	IMP
biological_process	GO:0072282	metanephric nephron tubule morphogenesis	IMP
biological_process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP
biological_process	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis	IGI
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IDA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016500	protein-hormone receptor activity	IEA

Pathways (from Reactome)

Pathway description

Regulation of FZD by ubiquitination

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Trps1^tm1Ymur/Trps1^tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg} Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0001148	enlarged testes	"increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ
MP:0001218	thin epidermis	"reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Trps1^tm1Ymur/Trps1^tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: E2f1^tm1Meg/E2f1^tm1Meg,E2f3^tm4Gle/E2f3^tm4Gle Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Tg(KRT5-cre)1Tak/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001313	increased incidence of corneal inflammation	"greater than average and persistent occurrence of corneal irritation" [J:4606]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg} Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg} Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Lgr5^tm2.1Cle/Lgr5^tm2.1Cle,Tg(Cyp1a1-cre)1Dwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Tg(Cyp1a1-cre)1Dwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002160	abnormal reproductive system morphology	"structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0002546	mydriasis	"dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002579	disorganized secondary lens fibers	"deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002631	abnormal epididymis morphology	"malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg} Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0002660	abnormal caput	"anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0002673	abnormal sperm count	"increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trps1^tm1Ymur/Trps1^tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003092	reduced corneal stroma thickness	"reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0003453	abnormal keratinocyte physiology	"atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003595	epididymal cyst	"benign growths present in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0003881	abnormal nephron morphology	"malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003941	abnormal skin development	"anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6 Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004221	abnormal iridocorneal angle	"any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004223	hypoplastic trabecular meshwork	"reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004505	decreased renal glomerulus number	"reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004728	abnormal efferent ductules of testis	"any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0004851	increased testis weight	"greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0004884	abnormal testicular physiology	"anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0004906	enlarged uterus		Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ
MP:0004929	decreased epididymis weight	"reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0004932	epididymis hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0004933	abnormal epididymis epithelium morphology	"any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0005193	abnormal anterior eye segment morphology	"anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005204	abnormal canal of Schlemm morphology	"structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005300	abnormal corneal stroma morphology	"structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005542	corneal vascularization	"formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005543	corneal thinning	"decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005544	corneal deposits	"accumulation of minerals, proteins, or other anomalous substances on the cornea" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006000	abnormal corneal epithelium	"malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006226	iris hypoplasia	"less than the normal number of cells in the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006230	iris stroma hypoplasia	"less than the normal number of cells in the iris stroma" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006319	abnormal epididymal fat pad	"any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0006416	abnormal rete testis morphology	"any structural anomaly of the network of canals at the termination of the straight tubules in the mediastinum testis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0006417	rete testis obstruction	"any impediment or blockage of the network of canals at the termination of the straight tubules in the mediastinum testis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0006423	dilated rete testis	"an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg}
MP:0008067	retinal ganglion cell degeneration	"degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008142	decreased small intestinal villus size	"reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Lgr5^tm2.1Cle/Lgr5^tm2.1Cle,Tg(Cyp1a1-cre)1Dwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Tg(Cyp1a1-cre)1Dwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008511	thin retinal inner nuclear layer	"reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008512	disorganized retinal inner nuclear layer	"derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008515	thin retinal outer nuclear layer	"reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008516	disorganized retinal outer nuclear layer	"derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009248	small caput	"decrease in the average size of the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010155	abnormal intestine physiology	"any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Espl1^Gt(XL058)Byg/Espl1⁺,Trp53^tm1Tyj/Trp53⁺ Genetic Background: B6.129-Trp53^tm1Tyj Espl1^Gt(XL058)Byg Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6 Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0010157	abnormal small intestinal crypt cell proliferation	"anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Lgr5^tm2.1Cle/Lgr5^tm2.1Cle,Tg(Cyp1a1-cre)1Dwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis,Tg(Cyp1a1-cre)1Dwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0010158	abnormal intestine development	"abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6 Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0010984	abnormal metanephric mesenchyme morphology	"any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0011006	abnormal epidermal stem cell proliferation	"anomaly in the ability of the a a somatic stem cell population that is part of the epidermis to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6 Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Il17rd^{Gt(KST223)Byg}/Il17rd⁺ Genetic Background: B6.129P2-Il17rd^{Gt(KST223)Byg} Allelic Composition: Lgr4^{Gt(pU-21)1Kymm}/Lgr4^{Gt(pU-21)1Kymm} Genetic Background: CBA.Cg-Lgr4^{Gt(pU-21)1Kymm} Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6 Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(Luc)Kael/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/NJ Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4⁺ Genetic Background: involves: 129P2/Ola * C57BL/6 Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lgr4^tm1.2Knis/Lgr4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6 Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0011365	small metanephros	"reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0011368	increased kidney apoptosis	"increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0011441	decreased kidney cell proliferation	"decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa},Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0011457	abnormal metanephric ureteric bud development	"any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502]	Show Allelic Composition: Lgr4^tm1.2Knis/Lgr4^tm1.2Knis Genetic Background: B6.129P2-Lgr4^tm1.2Knis
MP:0011481	anterior iris synechia	"adhesion of the iris to the cornea" [MGI:anna]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011499	abnormal glomerular capsule space morphology	"any structural anomaly of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]	Show Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Genetic Background: involves: C57BL/6
MP:0011750	abnormal seminiferous tubule epithelium morphology	"any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]	Show Allelic Composition: Lgr4^{Gt(pU-21)1Kymm}/Lgr4^{Gt(pU-21)1Kymm} Genetic Background: CBA.Cg-Lgr4^{Gt(pU-21)1Kymm} Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0013743	ciliary body hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the thickened portion of the vascular tunic which lies between the choroid and the iris" [ISBN:0-683-40008-8, MGI:Anna]	Show Allelic Composition: Lgr4^{Gt(LST020)Byg}/Lgr4^{Gt(LST020)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0014193	decreased epididymal cell proliferation	"decrease in the expansion rate of any epididymal cell population by cell division" [MGI:Anna]	Show Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028871	Rspo1 / R-spondin 1 / Q2MKA7*	/ complex / reaction
ENSMUSG00000032852	Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*	/ complex / reaction
ENSMUSG00000034177	Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*	/ reaction / complex
ENSMUSG00000041961	Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*	/ complex / reaction
ENSMUSG00000051920	Rspo2 / Q8BFU0 / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q6UXX9* / R-spondin 2*	/ reaction / complex
ENSMUSG00000019880	Rspo3 / Q2TJ95 / R-spondin-3 / Q9BXY4*	/ complex / reaction

0 s.

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