ENSGALG00000040834


Gallus gallus

Features
Gene ID: ENSGALG00000040834
  
Biological name :LGR4
  
Synonyms : leucine rich repeat containing G protein-coupled receptor 4 / LGR4
  
Possible biological names infered from orthology : A2ARI4 / Q9BXB1
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 3605922
Gene end: 3668629
  
Corresponding Affymetrix probe sets: Gga.8786.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049943
NCBI entrez gene - 428605     See in Manteia.
RefSeq - XM_426162
swissprot - A0A1D5PB24
Ensembl - ENSGALG00000040834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgr4ENSDARG00000060542Danio rerio
 LGR4ENSG00000205213Homo sapiens
 Lgr4ENSMUSG00000050199Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGR5 / leucine rich repeat containing G protein-coupled receptor 5 / O75473* / Q9Z1P4*ENSGALG0000001016346
LGR6 / leucine rich repeat containing G protein-coupled receptor 6 / Q3UVD5* / Q9HBX8*ENSGALG0000000056818
LHCGR / lutropin-choriogonadotropic hormone receptor precursor / P30730* / P22888* / AC073082.1* / Lutropin-choriogonadotropic hormone receptor * / luteinizing hormone/choriogonadotropin receptor*ENSGALG0000000909518
TSHR / thyrotropin receptor isoform 2 precursor / P16473* / P47750* / thyroid stimulating hormone receptor*ENSGALG0000001057217
FSHR / follicle-stimulating hormone receptor precursor / P23945* / P35378* / follicle stimulating hormone receptor*ENSGALG0000000910017
ENSGALG0000002976416
RXFP1 / relaxin/insulin like family peptide receptor 1 / Q6R6I7* / Q9HBX9* / Relaxin receptor 1 *ENSGALG0000000942915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0035239 tube morphogenesis IEA
 biological_processGO:0036335 intestinal stem cell homeostasis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050673 epithelial cell proliferation IEA
 biological_processGO:0050710 negative regulation of cytokine secretion IEA
 biological_processGO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development IEA
 biological_processGO:0072202 cell differentiation involved in metanephros development IEA
 biological_processGO:0072224 metanephric glomerulus development IEA
 biological_processGO:0072282 metanephric nephron tubule morphogenesis IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001028 RNF43 / ring finger protein 43 / Q5NCP0* / Q68DV7* / E3 ubiquitin-protein ligase RNF43 *  / complex / reaction
 ENSGALG00000001946 RSPO1 / R-spondin-1 precursor / Q2MKA7* / R-spondin 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000030030 RSPO2 / R-spondin-2 precursor / Q8BFU0* / Q6UXX9* / R-spondin 2* / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA.*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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