ENSGALG00000010163


Gallus gallus

Features
Gene ID: ENSGALG00000010163
  
Biological name :LGR5
  
Synonyms : leucine rich repeat containing G protein-coupled receptor 5 / LGR5
  
Possible biological names infered from orthology : O75473 / Q9Z1P4
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 36248569
Gene end: 36332580
  
Corresponding Affymetrix probe sets: Gga.14283.1.S1_at (Chicken Array)   GgaAffx.23149.1.S1_at (Chicken Array)   GgaAffx.23149.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016507
NCBI entrez gene - 427867     See in Manteia.
RefSeq - XM_425441
swissprot - E1C2F8
Ensembl - ENSGALG00000010163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGR5ENSG00000139292Homo sapiens
 Lgr5ENSMUSG00000020140Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGR4 / leucine rich repeat containing G protein-coupled receptor 4 / A2ARI4* / Q9BXB1*ENSGALG0000004083448
LGR6 / leucine rich repeat containing G protein-coupled receptor 6 / Q3UVD5* / Q9HBX8*ENSGALG0000000056823
LHCGR / lutropin-choriogonadotropic hormone receptor precursor / P30730* / P22888* / AC073082.1* / Lutropin-choriogonadotropic hormone receptor * / luteinizing hormone/choriogonadotropin receptor*ENSGALG0000000909520
TSHR / thyrotropin receptor isoform 2 precursor / P16473* / P47750* / thyroid stimulating hormone receptor*ENSGALG0000001057219
FSHR / follicle-stimulating hormone receptor precursor / P23945* / P35378* / follicle stimulating hormone receptor*ENSGALG0000000910018
RXFP1 / relaxin/insulin like family peptide receptor 1 / Q6R6I7* / Q9HBX9* / Relaxin receptor 1 *ENSGALG0000000942917
ENSGALG0000002976417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0009994 oocyte differentiation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032588 trans-Golgi network membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001028 RNF43 / ring finger protein 43 / Q5NCP0* / Q68DV7* / E3 ubiquitin-protein ligase RNF43 *  / complex / reaction
 ENSGALG00000030030 RSPO2 / R-spondin-2 precursor / Q8BFU0* / Q6UXX9* / R-spondin 2* / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA.*  / complex / reaction
 ENSGALG00000001946 RSPO1 / R-spondin-1 precursor / Q2MKA7* / R-spondin 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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