| MP:0000351 | increased cell proliferation | "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
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| MP:0000379 | reduced hair follicle number | "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Rab11atm1.1Ngao/Rab11atm1.1Ngao,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
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| MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Lgr5tm1(cre/ERT2)Cle/Lgr5+,Lrig1tm1.1(cre/ERT2)Rjc/Lrig1tm1.1(cre/ERT2)Rjc
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
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| MP:0000762 | abnormal tongue morphology | "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0001218 | thin epidermis | "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0001270 | distended abdomen | "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0001436 | abnormal suckling behavior | "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0001658 | increased mortality induced by gamma-irradiation | "greater sensitivity to doses of ionizing radiation" [J:51834] |
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Allelic Composition: Mstntm1Sjl/Mstn+
Genetic Background: B6N.129-Mstntm1Sjl
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| MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Lgr5tm2.1Cle/Lgr5tm2.1Cle,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0002404 | intestinal adenoma | "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Lgr5tm1(cre/ERT2)Cle/Lgr5+,Lrig1tm1.1(cre/ERT2)Rjc/Lrig1tm1.1(cre/ERT2)Rjc
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0003091 | abnormal cell migration | "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
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| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
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| MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0003704 | abnormal hair follicle development | "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0003941 | abnormal skin development | "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0004841 | abnormal small intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
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| MP:0004843 | abnormal Paneth cell morphology | "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008011 | intestinal polyps | "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1+,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0008142 | decreased small intestinal villus size | "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Lgr5tm2.1Cle/Lgr5tm2.1Cle,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0008800 | increased small intestinal crypt cell apoptosis | "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0009546 | absent gastric milk in neonates | "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
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| MP:0009764 | decreased sensitivity to induced morbidity/mortality | "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu,Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0010155 | abnormal intestine physiology | "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg
Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0010156 | abnormal small intestinal crypt cell physiology | "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
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| MP:0010157 | abnormal small intestinal crypt cell proliferation | "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Lgr5tm2.1Cle/Lgr5tm2.1Cle,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0010158 | abnormal intestine development | "abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
Allelic Composition: Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011006 | abnormal epidermal stem cell proliferation | "anomaly in the ability of the a a somatic stem cell population that is part of the epidermis to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(DTR/EGFP)Fjs,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0011441 | decreased kidney cell proliferation | "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna] |
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Allelic Composition: Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa,Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa
Genetic Background: involves: C57BL/6
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| MP:0013264 | tongue ankylosis | "partial or complete fusion or adherence of the tongue to the floor of the mouth, resulting in varying degrees of restricted tongue mobility; partial ankyloglossia (aka tongue-tie) is caused by a lingual frenulum that is abnormally short or is attached too close to the tip of the tongue; in complete ankyloglossia the tongue is tethered to the floor of the mouth" [MGI:anna] |
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6
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| MP:0013481 | abnormal ileum crypts of Lieberkuhn morphology | "any structural anomaly of the intestinal crypts located in the mucosa of the ileum, the portion of the small intestine that extends from the jejunum to the colon" [MGI:Anna] |
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Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
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| MP:0013485 | increased Paneth cell number | "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0013486 | decreased Paneth cell number | "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0013487 | abnormal Paneth cell physiology | "any functional anomaly of the large secretory cells found at the base of the crypts of Lieberkuhn in the small intestine; Paneth cells contribute to the mucosal defense mechanism through the secretion of granules filled with antimicrobial (poly)peptides such as lysozyme, phospholipase A2, and defensins (called cryptdins in mice); Paneth cells secrete factors that help sustain and modulate the epithelial stem and progenitor cells that cohabitate in the crypts of Lieberkuhn and rejuvenate the small intestinal epithelium; dysfunction of Paneth cell biology contributes to the pathogenesis of chronic inflammatory bowel disease" [PMID:23398152] |
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Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0014076 | absent Paneth cells | "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0014077 | ectopic Paneth cells | "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
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