ENSG00000146374


Homo sapiens

Features
Gene ID: ENSG00000146374
  
Biological name :RSPO3
  
Synonyms : Q9BXY4 / RSPO3 / R-spondin 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q22.33
Gene start: 127118604
Gene end: 127197765
  
Corresponding Affymetrix probe sets: 228186_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349131
Ensembl peptide - ENSP00000357300
NCBI entrez gene - 84870     See in Manteia.
OMIM - 610574
RefSeq - XM_017011379
RefSeq - NM_032784
RefSeq - XM_017011378
RefSeq Peptide - NP_116173
swissprot - Q9BXY4
Ensembl - ENSG00000146374
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rspo3ENSDARG00000070081Danio rerio
 RSPO3ENSGALG00000042607Gallus gallus
 Rspo3ENSMUSG00000019880Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RSPO1 / Q2MKA7 / R-spondin 1ENSG0000016921842
RSPO2 / Q6UXX9 / R-spondin 2ENSG0000014765540
RSPO4 / Q2I0M5 / R-spondin 4ENSG0000010128231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001974 blood vessel remodeling ISS
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway TAS
 biological_processGO:0030177 positive regulation of Wnt signaling pathway NAS
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway ISS
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway TAS
 cellular_componentGO:0005576 extracellular region NAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination
RUNX1 regulates transcription of genes involved in WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139292 LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5  / complex / reaction
 ENSG00000133067 LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6  / complex / reaction
 ENSG00000108375 RNF43 / Q68DV7 / ring finger protein 43  / reaction / complex
 ENSG00000183579 ZNRF3 / Q9ULT6 / zinc and ring finger 3  / reaction / complex
 ENSG00000205213 LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4  / complex / reaction






 

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