ENSMUSG00000024767


Mus musculus

Features
Gene ID: ENSMUSG00000024767
  
Biological name :Otub1
  
Synonyms : Otub1 / Q7TQI3 / Ubiquitin thioesterase OTUB1
  
Possible biological names infered from orthology : OTU deubiquitinase, ubiquitin aldehyde binding 1 / Q96FW1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 7198202
Gene end: 7206316
  
Corresponding Affymetrix probe sets: 10465625 (MoGene1.0st)   1417705_at (Mouse Genome 430 2.0 Array)   1448817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025679
Ensembl peptide - ENSMUSP00000122945
Ensembl peptide - ENSMUSP00000115195
NCBI entrez gene - 107260     See in Manteia.
MGI - MGI:2147616
RefSeq - NM_134150
RefSeq Peptide - NP_598911
swissprot - D3Z7K0
swissprot - D3YWF6
swissprot - Q7TQI3
Ensembl - ENSMUSG00000024767
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otub1aENSDARG00000055536Danio rerio
 otub1bENSDARG00000011462Danio rerio
 OTUB1ENSG00000167770Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otub2 / Q9CQX0 / Ubiquitin thioesterase OTUB2 / Q96DC9* / OTU deubiquitinase, ubiquitin aldehyde binding 2*ENSMUSG0000002120339


Protein motifs (from Interpro)
Interpro ID Name
 IPR003323  OTU domain
 IPR016615  Ubiquitin thioesterase Otubain
 IPR019400  Peptidase C65, otubain
 IPR030298  Ubiquitin thioesterase OTUB1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:1901315 negative regulation of histone H2A K63-linked ubiquitination IEA
 biological_processGO:2000780 negative regulation of double-strand break repair IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity ISO


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Nxntm1b(EUCOMM)Wtsi/Nxntm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nxntm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction / complex
 ENSMUSG00000031438 Q9D304 / Rnf128 / E3 ubiquitin-protein ligase RNF128 / Q8TEB7* / ring finger protein 128, E3 ubiquitin protein ligase*  / complex
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / reaction / complex






 

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