ENSG00000167770


Homo sapiens

Features
Gene ID: ENSG00000167770
  
Biological name :OTUB1
  
Synonyms : OTUB1 / OTU deubiquitinase, ubiquitin aldehyde binding 1 / Q96FW1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 63985853
Gene end: 64001811
  
Corresponding Affymetrix probe sets: 201245_s_at (Human Genome U133 Plus 2.0 Array)   201246_s_at (Human Genome U133 Plus 2.0 Array)   38710_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444357
Ensembl peptide - ENSP00000444968
Ensembl peptide - ENSP00000402551
Ensembl peptide - ENSP00000416973
Ensembl peptide - ENSP00000437453
Ensembl peptide - ENSP00000439142
Ensembl peptide - ENSP00000440211
Ensembl peptide - ENSP00000441328
NCBI entrez gene - 55611     See in Manteia.
OMIM - 608337
RefSeq - NM_017670
RefSeq Peptide - NP_060140
swissprot - F5H3F0
swissprot - F5H4F3
swissprot - F5H6Q1
swissprot - J3KR44
swissprot - Q96FW1
swissprot - F5GYJ8
swissprot - F5GYN4
Ensembl - ENSG00000167770
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otub1aENSDARG00000055536Danio rerio
 otub1bENSDARG00000011462Danio rerio
 Otub1ENSMUSG00000024767Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTUB2 / Q96DC9 / OTU deubiquitinase, ubiquitin aldehyde binding 2ENSG0000008972339


Protein motifs (from Interpro)
Interpro ID Name
 IPR003323  OTU domain
 IPR016615  Ubiquitin thioesterase Otubain
 IPR019400  Peptidase C65, otubain
 IPR030298  Ubiquitin thioesterase OTUB1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:1901315 negative regulation of histone H2A K63-linked ubiquitination IDA
 biological_processGO:2000780 negative regulation of double-strand break repair IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / complex
 ENSG00000133135 Q8TEB7 / RNF128 / ring finger protein 128, E3 ubiquitin protein ligase  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / reaction / complex






 

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