ENSG00000154342


Homo sapiens

Features
Gene ID: ENSG00000154342
  
Biological name :WNT3A
  
Synonyms : P56704 / WNT3A / Wnt family member 3A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.13
Gene start: 228007051
Gene end: 228061260
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000284523
NCBI entrez gene - 89780     See in Manteia.
OMIM - 606359
RefSeq - NM_033131
RefSeq - XM_011544319
RefSeq Peptide - NP_149122
swissprot - P56704
Ensembl - ENSG00000154342
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt3aENSDARG00000058822Danio rerio
 WNT3AENSGALG00000042657Gallus gallus
 Wnt3aENSMUSG00000009900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT3 / P56703 / Wnt family member 3ENSG0000010837984
WNT4 / P56705 / Wnt family member 4ENSG0000016255246
WNT5B / Q9H1J7 / Wnt family member 5BENSG0000011118646
WNT5A / P41221 / Wnt family member 5AENSG0000011425145
WNT1 / P04628 / Wnt family member 1ENSG0000012508443
WNT7B / P56706 / Wnt family member 7BENSG0000018806442
WNT2 / P09544 / Wnt family member 2ENSG0000010598942
WNT2B / Q93097 / Wnt family member 2BENSG0000013424542
WNT7A / O00755 / Wnt family member 7AENSG0000015476442
WNT6 / Q9Y6F9 / Wnt family member 6ENSG0000011559641
WNT16 / Q9UBV4 / Wnt family member 16ENSG0000000274540
WNT11 / O96014 / Wnt family member 11ENSG0000008574135


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009141  Wnt-3 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010387 COP9 signalosome assembly IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0021527 spinal cord association neuron differentiation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0021874 Wnt signaling pathway involved in forebrain neuroblast division IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033278 cell proliferation in midbrain IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0036465 synaptic vesicle recycling TAS
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0048337 positive regulation of mesodermal cell fate specification IDA
 biological_processGO:0048343 paraxial mesodermal cell fate commitment IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IEA
 biological_processGO:0048697 positive regulation of collateral sprouting in absence of injury IEA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060923 cardiac muscle cell fate commitment IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0061184 positive regulation of dermatome development IDA
 biological_processGO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IDA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0071300 cellular response to retinoic acid ISS
 biological_processGO:0090245 axis elongation involved in somitogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090676 calcium ion transmembrane transport via low voltage-gated calcium channel IEA
 biological_processGO:0099054 presynapse assembly TAS
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1904339 negative regulation of dopaminergic neuron differentiation IEA
 biological_processGO:1904798 positive regulation of core promoter binding IEA
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation TAS
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IEA
 biological_processGO:2000081 positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IDA
 biological_processGO:2001141 regulation of RNA biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome TAS
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0039706 co-receptor binding IPI
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000939 Osteoporosis "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO, osteoporosis is characterized by a value of BMD 2.5 standard deviations or more below the young adult mean." [HPO:curators]
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 HP:0001288 Gait disturbance "The term gait disturbance can refer to any disruption of the ability to walk. In general, this can refer to neurological diseases but also fractures or other sources of pain that is triggered upon walking. However, in the current context gait disturbance refers to difficulty walking on the basis of a neurological or muscular disease." [HPO:curators]
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 HP:0002653 Bone pain 
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 HP:0002757 Recurrent fractures "The repeated occurence of bone fractures (implying an abnormally increased tendency for fracture)." [HPO:curators]
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 HP:0002808 Kyphosis 
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 HP:0002953 Vertebral compression fractures 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction / complex
 ENSG00000103126 AXIN1 / O15169  / reaction / complex
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex
 ENSG00000145423 SFRP2 / Q96HF1 / secreted frizzled related protein 2  / complex / reaction
 ENSG00000156076 WIF1 / Q9Y5W5 / WNT inhibitory factor 1  / reaction / complex
 ENSG00000157240 FZD1 / Q9UP38 / frizzled class receptor 1  / reaction / complex
 ENSG00000180340 FZD2 / Q14332 / frizzled class receptor 2  / reaction / complex
 ENSG00000104332 SFRP1 / Q8N474 / secreted frizzled related protein 1  / reaction / complex
 ENSG00000070018 LRP6 / O75581 / LDL receptor related protein 6  / complex / reaction
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / reaction / complex
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / reaction / complex
 ENSG00000183579 ZNRF3 / Q9ULT6 / zinc and ring finger 3  / complex / reaction
 ENSG00000108375 RNF43 / Q68DV7 / ring finger protein 43  / complex / reaction






 

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