ENSG00000082701


Homo sapiens

Features
Gene ID: ENSG00000082701
  
Biological name :GSK3B
  
Synonyms : glycogen synthase kinase 3 beta / GSK3B / P49841
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q13.33
Gene start: 119821323
Gene end: 120094417
  
Corresponding Affymetrix probe sets: 209945_s_at (Human Genome U133 Plus 2.0 Array)   226183_at (Human Genome U133 Plus 2.0 Array)   226191_at (Human Genome U133 Plus 2.0 Array)   240562_at (Human Genome U133 Plus 2.0 Array)   242336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264235
Ensembl peptide - ENSP00000324806
NCBI entrez gene - 2932     See in Manteia.
OMIM - 605004
RefSeq - XM_006713611
RefSeq - NM_001146156
RefSeq - NM_002093
RefSeq - XM_006713610
RefSeq Peptide - NP_001139628
RefSeq Peptide - NP_002084
swissprot - P49841
swissprot - Q6FI27
Ensembl - ENSG00000082701
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsk3bENSDARG00000017803Danio rerio
 si:dkeyp-80c12.7ENSDARG00000052468Danio rerio
 GSK3BENSGALG00000014977Gallus gallus
 Gsk3bENSMUSG00000022812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSK3A / P49840 / glycogen synthase kinase 3 alphaENSG0000010572374
AC006486.1ENSG0000026864331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033573  Glycogen synthase kinase-3 beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IDA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006983 ER overload response IDA
 biological_processGO:0007212 dopamine receptor signaling pathway NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007623 circadian rhythm ISS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010822 positive regulation of mitochondrion organization IMP
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0031333 negative regulation of protein complex assembly IMP
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032092 positive regulation of protein binding ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity TAS
 biological_processGO:0032886 regulation of microtubule-based process IMP
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0036016 cellular response to interleukin-3 ISS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045719 negative regulation of glycogen biosynthetic process TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IC
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0046827 positive regulation of protein export from nucleus IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IC
 biological_processGO:0060079 excitatory postsynaptic potential NAS
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IMP
 biological_processGO:0071109 superior temporal gyrus development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IC
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISS
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand ISS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1900181 negative regulation of protein localization to nucleus ISS
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
 biological_processGO:1901215 negative regulation of neuron death IDA
 biological_processGO:1901216 positive regulation of neuron death IDA
 biological_processGO:1904339 negative regulation of dopaminergic neuron differentiation TAS
 biological_processGO:1904646 cellular response to amyloid-beta ISS
 biological_processGO:1904781 positive regulation of protein localization to centrosome IMP
 biological_processGO:1904885 beta-catenin destruction complex assembly TAS
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 biological_processGO:2000077 negative regulation of type B pancreatic cell development TAS
 biological_processGO:2000466 negative regulation of glycogen (starch) synthase activity TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030877 beta-catenin destruction complex TAS
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:1990909 Wnt signalosome TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0002039 p53 binding IDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI
 molecular_functionGO:0034452 dynactin binding IPI
 molecular_functionGO:0050321 tau-protein kinase activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
Ubiquitin-dependent degradation of Cyclin D1
Regulation of RUNX2 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / reaction / complex
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / reaction
 ENSG00000107882 SUFU / Q9UMX1 / SUFU negative regulator of hedgehog signaling  / reaction
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / reaction
 ENSG00000109670 FBXW7 / Q969H0 / F-box and WD repeat domain containing 7  / complex / reaction
 ENSG00000125084 WNT1 / P04628 / Wnt family member 1  / reaction / complex
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / reaction
 ENSG00000181274 FRAT2 / O75474 / FRAT2, WNT signaling pathway regulator  / complex / reaction
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / reaction
 ENSG00000075290 WNT8B / Q93098 / Wnt family member 8B  / complex / reaction
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000157240 FZD1 / Q9UP38 / frizzled class receptor 1  / reaction / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000061492 WNT8A / Q9H1J5 / Wnt family member 8A  / reaction / complex
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / reaction
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / complex / reaction
 ENSG00000180340 FZD2 / Q14332 / frizzled class receptor 2  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / reaction
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / reaction
 ENSG00000165879 FRAT1 / Q92837 / FRAT1, WNT signaling pathway regulator  / complex / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000154342 WNT3A / P56704 / Wnt family member 3A  / complex / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / reaction
 ENSG00000070018 LRP6 / O75581 / LDL receptor related protein 6  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / reaction
 ENSG00000103126 AXIN1 / O15169  / complex
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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