ENSG00000185122


Homo sapiens

Features
Gene ID: ENSG00000185122
  
Biological name :HSF1
  
Synonyms : heat shock transcription factor 1 / HSF1 / Q00613
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.3
Gene start: 144291591
Gene end: 144314722
  
Corresponding Affymetrix probe sets: 202344_at (Human Genome U133 Plus 2.0 Array)   213756_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481007
Ensembl peptide - ENSP00000431512
Ensembl peptide - ENSP00000484174
Ensembl peptide - ENSP00000383590
Ensembl peptide - ENSP00000480423
Ensembl peptide - ENSP00000436616
NCBI entrez gene - 3297     See in Manteia.
OMIM - 140580
RefSeq - XM_005272315
RefSeq - XM_017013377
RefSeq - XM_011517004
RefSeq - XM_005272317
RefSeq - XM_005272316
RefSeq - NM_005526
RefSeq Peptide - NP_005517
swissprot - Q00613
swissprot - E9PMQ6
swissprot - A0A087WWQ3
swissprot - A0A087WXG6
swissprot - A0A087X1F9
swissprot - E9PI02
Ensembl - ENSG00000185122
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsf1ENSDARG00000008818Danio rerio
 Hsf1ENSMUSG00000022556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSF2 / Q03933 / heat shock transcription factor 2ENSG0000002515634
HSF4 / Q9ULV5 / heat shock transcription factor 4ENSG0000010287833


Protein motifs (from Interpro)
Interpro ID Name
 IPR000232  Heat shock factor (HSF)-type, DNA-binding
 IPR010542  Vertebrate heat shock transcription factor, C-terminal domain
 IPR027725  Heat shock transcription factor family
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007143 female meiotic nuclear division IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009299 mRNA transcription IDA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0034620 cellular response to unfolded protein IDA
 biological_processGO:0034622 cellular protein-containing complex assembly IDA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035865 cellular response to potassium ion IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0060136 embryonic process involved in female pregnancy IEA
 biological_processGO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress IDA
 biological_processGO:0070207 protein homotrimerization IDA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IDA
 biological_processGO:0071280 cellular response to copper ion IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071478 cellular response to radiation IEA
 biological_processGO:0071480 cellular response to gamma radiation IDA
 biological_processGO:0072738 cellular response to diamide IDA
 biological_processGO:0090084 negative regulation of inclusion body assembly IEA
 biological_processGO:0090261 positive regulation of inclusion body assembly IEA
 biological_processGO:1900034 regulation of cellular response to heat IDA
 biological_processGO:1900365 positive regulation of mRNA polyadenylation IMP
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901652 response to peptide IEA
 biological_processGO:1902512 positive regulation of apoptotic DNA fragmentation IEA
 biological_processGO:1903936 cellular response to sodium arsenite IDA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904528 positive regulation of microtubule binding IEA
 biological_processGO:1904843 cellular response to nitroglycerin IEA
 biological_processGO:1904845 cellular response to L-glutamine IEA
 biological_processGO:1990910 response to hypobaric hypoxia IEA
 biological_processGO:1990911 response to psychosocial stress IEA
 biological_processGO:2001033 negative regulation of double-strand break repair via nonhomologous end joining IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000791 euchromatin IEA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0045120 pronucleus IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097165 nuclear stress granule IDA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 cellular_componentGO:1990904 ribonucleoprotein complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:0061770 translation elongation factor binding IDA
 molecular_functionGO:0097677 STAT family protein binding IEA
 molecular_functionGO:0098847 sequence-specific single stranded DNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / reaction / complex
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / reaction / complex
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / complex / reaction
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / reaction / complex
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / complex / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction / complex
 ENSG00000230989 HSBP1 / O75506 / heat shock factor binding protein 1  / reaction / complex






 

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