ENSG00000148660


Homo sapiens

Features
Gene ID: ENSG00000148660
  
Biological name :CAMK2G
  
Synonyms : calcium/calmodulin dependent protein kinase II gamma / CAMK2G / Q13555
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.2
Gene start: 73812501
Gene end: 73874591
  
Corresponding Affymetrix probe sets: 212669_at (Human Genome U133 Plus 2.0 Array)   212757_s_at (Human Genome U133 Plus 2.0 Array)   214322_at (Human Genome U133 Plus 2.0 Array)   238556_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393784
Ensembl peptide - ENSP00000378243
Ensembl peptide - ENSP00000405561
Ensembl peptide - ENSP00000410298
Ensembl peptide - ENSP00000277853
Ensembl peptide - ENSP00000307082
Ensembl peptide - ENSP00000315599
Ensembl peptide - ENSP00000319060
Ensembl peptide - ENSP00000361851
NCBI entrez gene - 818     See in Manteia.
OMIM - 602123
RefSeq - XM_017016739
RefSeq - XM_017016726
RefSeq - XM_017016727
RefSeq - XM_017016728
RefSeq - XM_017016729
RefSeq - XM_017016730
RefSeq - XM_017016731
RefSeq - XM_017016732
RefSeq - XM_017016733
RefSeq - XM_017016734
RefSeq - XM_017016735
RefSeq - XM_017016736
RefSeq - XM_017016737
RefSeq - XM_017016738
RefSeq - NM_001204492
RefSeq - NM_001222
RefSeq - NM_001320898
RefSeq - NM_172169
RefSeq - NM_172170
RefSeq - NM_172171
RefSeq - NM_172173
RefSeq - XM_005270195
RefSeq - XM_005270197
RefSeq - XM_005270198
RefSeq - XM_005270199
RefSeq - XM_005270200
RefSeq - XM_005270201
RefSeq - XM_005270203
RefSeq - XM_005270205
RefSeq - XM_006717993
RefSeq - XM_006717996
RefSeq - XM_006717997
RefSeq - XM_006717998
RefSeq - XM_011540225
RefSeq - XM_017016716
RefSeq - XM_017016717
RefSeq - XM_017016718
RefSeq - XM_017016719
RefSeq - XM_017016720
RefSeq - XM_017016721
RefSeq - XM_017016722
RefSeq - XM_017016723
RefSeq - XM_017016724
RefSeq - XM_017016725
RefSeq Peptide - NP_751913
RefSeq Peptide - NP_751910
RefSeq Peptide - NP_001191421
RefSeq Peptide - NP_001213
RefSeq Peptide - NP_001307827
RefSeq Peptide - NP_751909
RefSeq Peptide - NP_751911
swissprot - Q5SWX3
swissprot - H0Y6G2
swissprot - Q13555
swissprot - A0A0A0MT11
swissprot - Q8WU40
swissprot - A0A0A0MS52
Ensembl - ENSG00000148660
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk2g1ENSDARG00000071395Danio rerio
 camk2g2ENSDARG00000056206Danio rerio
 CAMK2GENSGALG00000005088Gallus gallus
 Camk2gENSMUSG00000021820Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II betaENSG0000005840484
CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II deltaENSG0000014534979
CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alphaENSG0000007080873
CAMK4 / Q16566 / calcium/calmodulin dependent protein kinase IVENSG0000015249526
CAMK1G / Q96NX5 / calcium/calmodulin dependent protein kinase IGENSG0000000811826
CAMK1 / Q14012 / calcium/calmodulin dependent protein kinase IENSG0000013407224
CAMK1D / Q8IU85 / calcium/calmodulin dependent protein kinase IDENSG0000018304924
PNCK / Q6P2M8 / pregnancy up-regulated nonubiquitous CaM kinaseENSG0000013082224
CAMKV / Q8NCB2 / CaM kinase like vesicle associatedENSG0000016407622
PSKH1 / P11801 / protein serine kinase H1ENSG0000015979220
PSKH2 / Q96QS6 / protein serine kinase H2ENSG0000014761319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0014733 regulation of skeletal muscle adaptation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030073 insulin secretion NAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051924 regulation of calcium ion transport TAS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901897 regulation of relaxation of cardiac muscle IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0004723 calcium-dependent protein serine/threonine phosphatase activity NAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / reaction / complex
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction / complex
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction / complex
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / complex / reaction
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / complex / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / complex / reaction
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction






 

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