Manteia

ENSG00000070808

Homo sapiens

Features

Gene ID:	ENSG00000070808

Biological name :	CAMK2A

Synonyms :	calcium/calmodulin dependent protein kinase II alpha / CAMK2A / Q9UQM7

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	5
Strand:	-1
Band:	q32
Gene start:	150219491
Gene end:	150290291

Corresponding Affymetrix probe sets:	207613_s_at (Human Genome U133 Plus 2.0 Array) 213108_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000261793 Ensembl peptide - ENSP00000427580 Ensembl peptide - ENSP00000426607 Ensembl peptide - ENSP00000381412 NCBI entrez gene - 815 See in Manteia. OMIM - 114078 RefSeq - NM_015981 RefSeq - XM_017009898 RefSeq - NM_171825 RefSeq Peptide - NP_057065 RefSeq Peptide - NP_741960 swissprot - D6RHX9 swissprot - D6RFJ0 swissprot - Q7LDD5 swissprot - Q9UQM7 swissprot - A8K161 Ensembl - ENSG00000070808

Related genetic diseases (OMIM):	617798 - Mental retardation, autosomal dominant 53, 617798

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
camk2a	ENSDARG00000053617	Danio rerio
CAMK2A	ENSGALG00000005621	Gallus gallus
Camk2a	ENSMUSG00000024617	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta	ENSG00000145349	86
CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta	ENSG00000058404	84
CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma	ENSG00000148660	83
CAMK4 / Q16566 / calcium/calmodulin dependent protein kinase IV	ENSG00000152495	29
CAMK1G / Q96NX5 / calcium/calmodulin dependent protein kinase IG	ENSG00000008118	28
CAMK1 / Q14012 / calcium/calmodulin dependent protein kinase I	ENSG00000134072	27
PNCK / Q6P2M8 / pregnancy up-regulated nonubiquitous CaM kinase	ENSG00000130822	27
CAMK1D / Q8IU85 / calcium/calmodulin dependent protein kinase ID	ENSG00000183049	27
CAMKV / Q8NCB2 / CaM kinase like vesicle associated	ENSG00000164076	24
PSKH1 / P11801 / protein serine kinase H1	ENSG00000159792	23
PSKH2 / Q96QS6 / protein serine kinase H2	ENSG00000147613	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain
IPR017441	Protein kinase, ATP binding site
IPR032710	NTF2-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	ISS
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0002931	response to ischemia	ISS
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0006816	calcium ion transport	ISS
biological_process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	TAS
biological_process	GO:0007399	nervous system development	IBA
biological_process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISS
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018105	peptidyl-serine phosphorylation	ISS
biological_process	GO:0018107	peptidyl-threonine phosphorylation	IBA
biological_process	GO:0030154	cell differentiation	IBA
biological_process	GO:0035556	intracellular signal transduction	IBA
biological_process	GO:0038166	angiotensin-activated signaling pathway	IDA
biological_process	GO:0046777	protein autophosphorylation	ISS
biological_process	GO:0046928	regulation of neurotransmitter secretion	ISS
biological_process	GO:0048168	regulation of neuronal synaptic plasticity	ISS
biological_process	GO:0048813	dendrite morphogenesis	IEA
biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP
biological_process	GO:0051928	positive regulation of calcium ion transport	ISS
biological_process	GO:0060333	interferon-gamma-mediated signaling pathway	TAS
biological_process	GO:1900034	regulation of cellular response to heat	TAS
biological_process	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	ISS
cellular_component	GO:0005634	nucleus	HDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005739	mitochondrion	ISS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0014069	postsynaptic density	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0030666	endocytic vesicle membrane	TAS
cellular_component	GO:0042734	presynaptic membrane	IEA
cellular_component	GO:0043005	neuron projection	IBA
cellular_component	GO:0045202	synapse	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	ISS
molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	IMP
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005516	calmodulin binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IMP
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0035254	glutamate receptor binding	ISS
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IPI
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

HSF1-dependent transactivation

Trafficking of AMPA receptors

Ca2+ pathway

Unblocking of NMDA receptor, glutamate binding and activation

CREB phosphorylation through the activation of CaMKII

CREB phosphorylation through the activation of Ras

Ras activation upon Ca2+ influx through NMDA receptor

Phase 0 - rapid depolarisation

Ion homeostasis

RAF/MAP kinase cascade

Interferon gamma signaling

Ion transport by P-type ATPases

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000033122	LRRC7 / Q96NW7 / leucine rich repeat containing 7	/ reaction / complex
ENSG00000082458	DLG3 / Q92796 / discs large MAGUK scaffold protein 3	/ reaction / complex
ENSG00000105464	GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D	/ reaction / complex
ENSG00000113319	O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2	/ reaction / complex
ENSG00000120251	GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2	/ reaction
ENSG00000058404	CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta	/ reaction / complex
ENSG00000155511	GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1	/ reaction
ENSG00000152578	GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4	/ reaction
ENSG00000150672	DLG2 / Q15700 / discs large MAGUK scaffold protein 2	/ reaction / complex
ENSG00000132535	DLG4 / P78352 / discs large MAGUK scaffold protein 4	/ complex / reaction
ENSG00000161509	GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C	/ reaction / complex
ENSG00000148660	CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma	/ complex / reaction
ENSG00000145349	CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta	/ reaction / complex
ENSG00000183454	GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A	/ reaction / complex
ENSG00000127914	AKAP9 / Q99996 / A-kinase anchoring protein 9	/ reaction / complex
ENSG00000126458	RRAS / P10301 / RAS related	/ reaction
ENSG00000277586	NEFL / P07196 / neurofilament light	/ complex / reaction
ENSG00000115415	STAT1 / P42224 / signal transducer and activator of transcription 1	/ reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ reaction
ENSG00000027697	IFNGR1 / P15260 / interferon gamma receptor 1	/ reaction
ENSG00000111537	IFNG / P01579 / interferon gamma	/ reaction
ENSG00000070808	CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha	/ reaction / complex
ENSG00000185122	HSF1 / Q00613 / heat shock transcription factor 1	/ reaction
ENSG00000176884	GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1	/ complex / reaction
ENSG00000118260	CREB1 / P16220 / cAMP responsive element binding protein 1	/ reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000273079	GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B	/ complex / reaction
ENSG00000162434	JAK1 / P23458 / Janus kinase 1	/ reaction
ENSG00000198668	CALM1 / P0DP23 / calmodulin 1	/ complex / reaction
ENSG00000159128	IFNGR2 / P38484 / interferon gamma receptor 2	/ reaction
ENSG00000077522	ACTN2 / P35609 / actinin alpha 2	/ complex / reaction
ENSG00000157764	BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase	/ reaction
ENSG00000075711	DLG1 / Q12959 / discs large MAGUK scaffold protein 1	/ complex / reaction
ENSG00000135341	MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7	/ reaction / complex
ENSG00000058335	Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1	/ reaction / complex
ENSG00000125675	GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr