ENSG00000120251


Homo sapiens

Features
Gene ID: ENSG00000120251
  
Biological name :GRIA2
  
Synonyms : glutamate ionotropic receptor AMPA type subunit 2 / GRIA2 / P42262
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.1
Gene start: 157204182
Gene end: 157366075
  
Corresponding Affymetrix probe sets: 205358_at (Human Genome U133 Plus 2.0 Array)   236538_at (Human Genome U133 Plus 2.0 Array)   241172_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423229
Ensembl peptide - ENSP00000423988
Ensembl peptide - ENSP00000495569
Ensembl peptide - ENSP00000426845
Ensembl peptide - ENSP00000426784
Ensembl peptide - ENSP00000426513
Ensembl peptide - ENSP00000425217
Ensembl peptide - ENSP00000264426
Ensembl peptide - ENSP00000296526
Ensembl peptide - ENSP00000318144
Ensembl peptide - ENSP00000377403
Ensembl peptide - ENSP00000422038
NCBI entrez gene - 2891     See in Manteia.
OMIM - 138247
RefSeq - XM_017008117
RefSeq - NM_000826
RefSeq - NM_001083619
RefSeq - NM_001083620
RefSeq - XM_017008113
RefSeq - XM_017008114
RefSeq - XM_017008115
RefSeq - XM_017008116
RefSeq Peptide - NP_000817
RefSeq Peptide - NP_001077088
RefSeq Peptide - NP_001077089
swissprot - P42262
swissprot - D6RBV7
swissprot - D6R9Z0
swissprot - F8W7L6
swissprot - H0Y972
swissprot - D6RDX5
swissprot - D6RFM6
swissprot - D6REK8
Ensembl - ENSG00000120251
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gria2aENSDARG00000070173Danio rerio
 gria2bENSDARG00000052765Danio rerio
 GRIA2ENSGALG00000009405Gallus gallus
 Gria2ENSMUSG00000033981Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257872
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567571
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551168
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441839
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118938
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387337
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940335
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573734
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277127
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220826
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307921
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688421
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150921
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345420
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546419
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878518
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001638  Solute-binding protein family 3/N-terminal domain of MltF
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic TAS
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009897 external side of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0032281 AMPA glutamate receptor complex ISS
 cellular_componentGO:0043197 dendritic spine NAS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse NAS
 cellular_componentGO:0098794 postsynapse TAS
 cellular_componentGO:0098843 postsynaptic endocytic zone NAS
 cellular_componentGO:0106003 amyloid-beta complex ISS
 molecular_functionGO:0001540 amyloid-beta binding NAS
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004971 AMPA glutamate receptor activity TAS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005231 excitatory extracellular ligand-gated ion channel activity TAS
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / complex / reaction
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / complex / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / reaction
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / complex / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / reaction
 ENSG00000100151 PICK1 / Q9NRD5 / protein interacting with PRKCA 1  / reaction






 

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