ENSMUSG00000033981


Mus musculus

Features
Gene ID: ENSMUSG00000033981
  
Biological name :Gria2
  
Synonyms : glutamate receptor 2 isoform 3 / Gria2
  
Possible biological names infered from orthology : glutamate ionotropic receptor AMPA type subunit 2 / P42262
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 80681450
Gene end: 80802835
  
Corresponding Affymetrix probe sets: 10498885 (MoGene1.0st)   1421970_a_at (Mouse Genome 430 2.0 Array)   1434146_at (Mouse Genome 430 2.0 Array)   1438057_at (Mouse Genome 430 2.0 Array)   1453098_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141447
Ensembl peptide - ENSMUSP00000074787
Ensembl peptide - ENSMUSP00000103374
NCBI entrez gene - 14800     See in Manteia.
MGI - MGI:95809
RefSeq - XM_006501015
RefSeq - NM_001039195
RefSeq - NM_001083806
RefSeq - NM_013540
RefSeq - XM_006501012
RefSeq - XM_006501013
RefSeq - XM_006501014
RefSeq Peptide - NP_001077275
RefSeq Peptide - NP_038568
RefSeq Peptide - NP_001034284
swissprot - G5E8H1
swissprot - E9QKC0
swissprot - A0A0A6YW90
Ensembl - ENSMUSG00000033981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gria2aENSDARG00000070173Danio rerio
 gria2bENSDARG00000052765Danio rerio
 GRIA2ENSGALG00000009405Gallus gallus
 GRIA2ENSG00000120251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589273
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198671
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052468
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607339
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293538
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198537
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201735
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337834
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107828
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142426
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073422
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695922
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020921
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900320
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277119
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574518
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Activation of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

Allelic Composition: Gria2tm1Rod/Gria2+,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Gnrh1-cre)1Rsp/0
Genetic Background: involves: C57BL/6

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Gnrh1-cre)1Rsp/0
Genetic Background: involves: C57BL/6

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Gnrh1-cre)1Rsp/0
Genetic Background: involves: C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001401 jumpy "marked by fitful, jerky movements" [J:22295]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob
Genetic Background: B6.129S(Cg)-Hoxa5tm1Rob

Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tw/Foxn1tw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-7J/Myo7ash1-7J
Genetic Background: STOCK Myo7ash1-7J/J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm2Imat/Otx2tm2Imat
Genetic Background: involves: C57BL/6 * CBA

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Gnrh1-cre)1Rsp/0
Genetic Background: involves: C57BL/6

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pofut1tm1Pst/Pofut1cax
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0002918 abnormal paired-pulse facilitation "defects in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Gnrh1-cre)1Rsp/0
Genetic Background: involves: C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Gria2*586N)238.2Rsp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008532 decreased chemical nociceptive threshold "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6.Cg-Gria2tm1Rod Tg(SOD1*G93A)1Gur

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod
Genetic Background: B6.129-Gria2tm1Rod/J

Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011002 enhanced AMPA-mediated synaptic currents "increase in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hoxa4tm1Mrc/Hoxa4tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Gria2tm2Rsp/Gria2tm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gria2tm2.1Rsp/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gria2tm1Rod/Gria2tm1Rod,Gria3tm1Zpj/Y
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0020478 abnormal circadian sleep/wake cycle "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745]
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Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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