ENSMUSG00000056073


Mus musculus

Features
Gene ID: ENSMUSG00000056073
  
Biological name :Grik2
  
Synonyms : Glutamate receptor ionotropic, kainate 2 / Grik2 / P39087
  
Possible biological names infered from orthology : glutamate ionotropic receptor kainate type subunit 2 / Q13002
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B3
Gene start: 49094833
Gene end: 49788766
  
Corresponding Affymetrix probe sets: 10368999 (MoGene1.0st)   1425790_a_at (Mouse Genome 430 2.0 Array)   1445234_at (Mouse Genome 430 2.0 Array)   1457683_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151921
Ensembl peptide - ENSMUSP00000151671
Ensembl peptide - ENSMUSP00000151982
Ensembl peptide - ENSMUSP00000152029
Ensembl peptide - ENSMUSP00000078687
Ensembl peptide - ENSMUSP00000101124
Ensembl peptide - ENSMUSP00000151372
Ensembl peptide - ENSMUSP00000151389
NCBI entrez gene - 14806     See in Manteia.
MGI - MGI:95815
RefSeq - XM_017313804
RefSeq - XM_011243120
RefSeq - XM_011243121
RefSeq - XM_011243122
RefSeq - XM_011243123
RefSeq - XM_011243124
RefSeq - XM_011243125
RefSeq - XM_011243127
RefSeq - NM_001111268
RefSeq - NM_010349
RefSeq - XM_006512545
RefSeq Peptide - NP_034479
RefSeq Peptide - NP_001104738
swissprot - Q6PAQ0
swissprot - A0A1W2P8D9
swissprot - P39087
swissprot - A0A1W2P6S5
swissprot - A0A1W2P868
Ensembl - ENSMUSG00000056073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRIK2ENSDARG00000113771Danio rerio
 GRIK2ENSGALG00000015434Gallus gallus
 GRIK2ENSG00000164418Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198579
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293578
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337844
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201743
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398138
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052438
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198638
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589237
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107828
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142427
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900321
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020920
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277120
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574519
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695919
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073419
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0019228 neuronal action potential IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity ISO
 biological_processGO:0050804 modulation of chemical synaptic transmission ISO
 biological_processGO:0050806 positive regulation of synaptic transmission ISO
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IGI
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060080 inhibitory postsynaptic potential IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IC
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0032983 kainate selective glutamate receptor complex IPI
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IMP
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008066 glutamate receptor activity IEA
 molecular_functionGO:0015277 kainate selective glutamate receptor activity ISO
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of Na-permeable kainate receptors
Activation of Ca-permeable Kainate Receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tor1atm2Wtd/Tor1a+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grik2tm1Sfh/Grik2tm1Sfh
Genetic Background: involves: 129S1/Sv

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grik2tm1Bvis/Grik2tm1Bvis
Genetic Background: 129S/Sv-Grik2tm1Bvis

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Grik2tm1Bvis/Grik2tm1Bvis
Genetic Background: 129S/Sv-Grik2tm1Bvis

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Grik2tm1Bvis/Grik2tm1Bvis
Genetic Background: 129S/Sv-Grik2tm1Bvis

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grik2tm1Sfh/Grik2tm1Sfh
Genetic Background: involves: 129S1/Sv

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Grik1tm1Sfh/Grik1tm1Sfh,Grik2tm1Sfh/Grik2tm1Sfh
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Fgf4tm1.2Mrt/Fgf4tm1.3Mrt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Grik2tm1Bvis/Grik2tm1Bvis
Genetic Background: 129S/Sv-Grik2tm1Bvis

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000003378 Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000032017 Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*  / complex
 ENSMUSG00000001985 Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*  / complex
 ENSMUSG00000056073 Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*  / reaction / complex






 

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