ENSMUSG00000032017


Mus musculus

Features
Gene ID: ENSMUSG00000032017
  
Biological name :Grik4
  
Synonyms : Glutamate receptor ionotropic, kainate 4 / Grik4 / Q8BMF5
  
Possible biological names infered from orthology : glutamate ionotropic receptor kainate type subunit 4 / Q16099
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.1
Gene start: 42518135
Gene end: 42944493
  
Corresponding Affymetrix probe sets: 10592629 (MoGene1.0st)   1437681_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034515
Ensembl peptide - ENSMUSP00000110515
NCBI entrez gene - 110637     See in Manteia.
MGI - MGI:95817
RefSeq - XM_017313104
RefSeq - NM_175481
RefSeq - XM_017313102
RefSeq - XM_017313103
RefSeq - XM_006509941
RefSeq - XM_006509942
RefSeq - XM_006509943
RefSeq - XM_011242383
RefSeq Peptide - NP_780690
swissprot - Q8BMF5
Ensembl - ENSMUSG00000032017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grik4ENSDARG00000026753Danio rerio
 GRIK4ENSGALG00000006638Gallus gallus
 GRIK4ENSG00000149403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337869
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607341
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293540
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198538
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052433
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198633
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589232
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398132
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107825
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142424
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695920
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900320
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020920
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277120
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073419
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574518
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032983 kainate selective glutamate receptor complex IPI
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of Ca-permeable Kainate Receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Tyrc-a/Tyrc-h
Genetic Background: involves: C3H/HeJ

 MP:0001901 absence of NMDA -mediated synaptic currents "absence of a measured amplitude or response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-a/Tyrc-h
Genetic Background: involves: C3H/HeJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-a/Tyrc-h
Genetic Background: involves: C3H/HeJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grik4tm1.1Sfh/Grik4tm1.1Sfh
Genetic Background: involves: 129S4/SvJae

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Grik4tm1.1Sfh/Grik4tm1.1Sfh,Grik5tm1Cont/Grik5tm1Cont
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-a/Tyrc-h
Genetic Background: involves: C3H/HeJ

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grik4tm1.1Sfh/Grik4tm1.1Sfh,Grik5tm1Cont/Grik5tm1Cont
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Grik4tm1.1Sfh/Grik4tm1.1Sfh
Genetic Background: involves: 129S4/SvJae

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Tyrc-a/Tyrc-h
Genetic Background: involves: C3H/HeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000056073 Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*  / complex
 ENSMUSG00000001985 Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000032017 Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*  / complex






 

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