ENSG00000149403


Homo sapiens

Features
Gene ID: ENSG00000149403
  
Biological name :GRIK4
  
Synonyms : glutamate ionotropic receptor kainate type subunit 4 / GRIK4 / Q16099
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 120511700
Gene end: 120988904
  
Corresponding Affymetrix probe sets: 208552_at (Human Genome U133 Plus 2.0 Array)   242215_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404063
Ensembl peptide - ENSP00000435648
Ensembl peptide - ENSP00000492086
NCBI entrez gene - 2900     See in Manteia.
OMIM - 600282
RefSeq - XM_017017622
RefSeq - NM_001282470
RefSeq - NM_001282473
RefSeq - NM_014619
RefSeq - XM_011542784
RefSeq - XM_011542786
RefSeq - XM_011542787
RefSeq - XM_017017621
RefSeq Peptide - NP_001269402
RefSeq Peptide - NP_055434
RefSeq Peptide - NP_001269399
swissprot - Q16099
Ensembl - ENSG00000149403
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grik4ENSDARG00000026753Danio rerio
 GRIK4ENSGALG00000006638Gallus gallus
 Grik4ENSMUSG00000032017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573766
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441841
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118939
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387338
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567533
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551133
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257832
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025132
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277125
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220824
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688420
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307920
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345420
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546420
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150919
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878517
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007215 glutamate receptor signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032983 kainate selective glutamate receptor complex IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015277 kainate selective glutamate receptor activity TAS


Pathways (from Reactome)
Pathway description
Activation of Ca-permeable Kainate Receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000149403 GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4  / complex
 ENSG00000164418 GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2  / complex
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / complex
 ENSG00000171189 GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1  / complex






 

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