ENSG00000163873


Homo sapiens

Features
Gene ID: ENSG00000163873
  
Biological name :GRIK3
  
Synonyms : glutamate ionotropic receptor kainate type subunit 3 / GRIK3 / Q13003
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.3
Gene start: 36795527
Gene end: 37034129
  
Corresponding Affymetrix probe sets: 207454_at (Human Genome U133 Plus 2.0 Array)   230593_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362185
Ensembl peptide - ENSP00000362183
NCBI entrez gene - 2899     See in Manteia.
OMIM - 138243
RefSeq - NM_000831
RefSeq Peptide - NP_000822
swissprot - Q13003
Ensembl - ENSG00000163873
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRIK3ENSDARG00000077715Danio rerio
 GRIK3ENSGALG00000002098Gallus gallus
 Grik3ENSMUSG00000001985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441878
GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1ENSG0000017118972
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573741
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940340
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551136
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025136
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257835
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567535
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277128
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220826
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307920
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345420
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546420
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688420
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603219
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150919
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878518


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA
 biological_processGO:0007215 glutamate receptor signaling pathway IDA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway IDA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032839 dendrite cytoplasm ISS
 cellular_componentGO:0043195 terminal bouton ISS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity IDA
 molecular_functionGO:0001664 G-protein coupled receptor binding TAS
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0008066 glutamate receptor activity TAS
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015277 kainate selective glutamate receptor activity IDA


Pathways (from Reactome)
Pathway description
Activation of Ca-permeable Kainate Receptor
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex
 ENSG00000105737 GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5  / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000171189 GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1  / complex
 ENSG00000149403 GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4  / complex
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / complex
 ENSG00000182621 PLCB1 / Q9NQ66 / phospholipase C beta 1  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000149782 PLCB3 / Q01970 / phospholipase C beta 3  / complex / reaction
 ENSG00000137841 PLCB2 / Q00722 / phospholipase C beta 2  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000164418 GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2  / complex






 

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