ENSG00000149782


Homo sapiens

Features
Gene ID: ENSG00000149782
  
Biological name :PLCB3
  
Synonyms : phospholipase C beta 3 / PLCB3 / Q01970
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64251523
Gene end: 64269150
  
Corresponding Affymetrix probe sets: 213384_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000279230
Ensembl peptide - ENSP00000324660
Ensembl peptide - ENSP00000443631
NCBI entrez gene - 5331     See in Manteia.
OMIM - 600230
RefSeq - XM_011545101
RefSeq - NM_000932
RefSeq - NM_001184883
RefSeq - NM_001316314
RefSeq Peptide - NP_001171812
RefSeq Peptide - NP_001303243
RefSeq Peptide - NP_000923
swissprot - Q01970
Ensembl - ENSG00000149782
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcb3ENSDARG00000068246Danio rerio
 Plcb3ENSMUSG00000024960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262154
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784143
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133336
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952723
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480523
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482222
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589621
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709120
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555620
PLCD3 / Q8N3E9 / phospholipase C delta 3ENSG0000016171419
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003073 regulation of systemic arterial blood pressure IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004629 phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Acetylcholine regulates insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / reaction / complex
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000137841 PLCB2 / Q00722 / phospholipase C beta 2  / reaction
 ENSG00000101333 PLCB4 / Q15147 / phospholipase C beta 4  / reaction
 ENSG00000182621 PLCB1 / Q9NQ66 / phospholipase C beta 1  / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / reaction / complex
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000149782 PLCB3 / Q01970 / phospholipase C beta 3  / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction






 

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