ENSDARG00000068246


Danio rerio

Features
Gene ID: ENSDARG00000068246
  
Biological name :plcb3
  
Synonyms : phospholipase C, beta 3 (phosphatidylinositol-specific) / plcb3
  
Possible biological names infered from orthology : P51432 / phospholipase C beta 3 / Q01970
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 60255852
Gene end: 60351876
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000138179
Ensembl peptide - ENSDARP00000089334
NCBI entrez gene - 100001532     See in Manteia.
RefSeq - XM_005166533
swissprot - Q7ZZ38
swissprot - A0A0R4IVA6
ZFIN ID - ZDB-GENE-030616-594
Ensembl - ENSDARG00000068246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB3ENSG00000149782Homo sapiens
 Plcb3ENSMUSG00000024960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCB1 / si:ch1073-140o9.2 / Q9NQ66* / Q9Z1B3* / phospholipase C beta 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *ENSDARG0000010972637
PLCB4 / phospholipase C beta 4 / Q15147*ENSDARG0000010078632
plcl2 / phospholipase C like 2 / Q8K394* / Q9UPR0* / Inactive phospholipase C-like protein 2 *ENSDARG0000009882621
PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *ENSDARG0000009038121
plch2a / phospholipase C, eta 2a / PLCH2* / A2AP18* / O75038* / phospholipase C eta 2* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSDARG0000005996020
si:ch211-210g13.5ENSDARG0000006257520
plch1 / phospholipase C, eta 1 / Q4KWH5* / Q4KWH8* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 *ENSDARG0000007925320
plcd3b / phospholipase C, delta 3b / PLCD3* / Q8N3E9* / Q8K2J0* / phospholipase C delta 3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSDARG0000007957220
plcd1b / phospholipase C, delta 1b / PLCD1* / P51178* / phospholipase C delta 1*ENSDARG0000003408019
plcd4a / phospholipase C, delta 4a / PLCD4* / Q8K3R3* / Q9BRC7* / phospholipase C delta 4*ENSDARG0000005797519
A5D6R3 / plcd3a / phospholipase C, delta 3a / PLCD3* / Q8N3E9* / Q8K2J0* / phospholipase C delta 3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSDARG0000005295719
plcd4b / phospholipase C, delta 4b / PLCD4* / Q8K3R3* / Q9BRC7* / phospholipase C delta 4*ENSDARG0000004068419
plcl1 / phospholipase C like 1 / Q15111* / Q3USB7* / phospholipase C like 1 (inactive)* / Inactive phospholipase C-like protein 1 *ENSDARG0000006767618
plcd1a / phospholipase C, delta 1a / PLCD1* / Q8R3B1* / P51178* / phospholipase C delta 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 *ENSDARG0000005912318
plch2b / phospholipase C, eta 2b / PLCH2* / A2AP18* / O75038* / phospholipase C eta 2* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSDARG0000005680517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR009535  Phospholipase C-beta, conserved site
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043116 negative regulation of vascular permeability IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0090281 negative regulation of calcium ion import IDA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton decreased length , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
Show

 ZFA:0000250 opercle opercle shape , abnormal
opercle size , abnormal
opercle increased size , abnormal
Show

 ZFA:0000476 branchiostegal ray branchiostegal ray decreased size , abnormal
branchiostegal ray aplastic , abnormal
Show

 ZFA:0000547 mouth mouth open , abnormal
mouth quality , abnormal
mouth concave 3-D shape , abnormal
Show

 ZFA:0000737 cranium cranium has extra parts of type cranial cartilage , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
pectoral fin quality , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
Meckels cartilage deformed , abnormal
Meckels cartilage decreased size , abnormal
Meckels cartilage mislocalised posteriorly , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium quality , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
mandibular arch skeleton decreased size , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch quality , abnormal
ventral mandibular arch decreased size , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton decreased size , abnormal
Show

 ZFA:0001280 branchiostegal ray 3 branchiostegal ray 3 shape , abnormal
branchiostegal ray 3 aplastic , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
palatoquadrate cartilage deformed , abnormal
palatoquadrate cartilage curved lateral , abnormal
palatoquadrate cartilage curved medial , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage mislocalised posteriorly , abnormal
ceratohyal cartilage inverted , abnormal
Show

 ZFA:0001402 ventral hyoid arch ventral hyoid arch morphology , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage decreased size , abnormal
hyosymplectic cartilage increased width , abnormal
Show

 ZFA:0001501 cartilage element cartilage element mislocalised , abnormal
Show

 ZFA:0005465 ceratohyal-branchiostegal ray joint ceratohyal-branchiostegal ray joint morphology , abnormal
Show

 ZFA:0005473 interhyal-epihyal joint interhyal-epihyal joint absent , abnormal
Show

 ZFA:0009031 osteoblast osteoblast decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000090381 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / reaction / complex
 ENSDARG00000100786 PLCB4 / phospholipase C beta 4 / Q15147*  / reaction
 ENSDARG00000068246 plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*  / reaction
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex






 

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