ENSDARG00000100786


Danio rerio

Features
Gene ID: ENSDARG00000100786
  
Biological name :PLCB4
  
Synonyms : phospholipase C beta 4 / PLCB4
  
Possible biological names infered from orthology : Q15147
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 3717384
Gene end: 3815693
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133895
swissprot - A0A0G2KNE7
Ensembl - ENSDARG00000100786
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB4ENSGALG00000008907Gallus gallus
 PLCB4ENSG00000101333Homo sapiens
 Plcb4ENSMUSG00000039943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*ENSDARG0000006824635
PLCB1 / si:ch1073-140o9.2 / Q9NQ66* / Q9Z1B3* / phospholipase C beta 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *ENSDARG0000010972625
plcl2 / phospholipase C like 2 / Q8K394* / Q9UPR0* / Inactive phospholipase C-like protein 2 *ENSDARG0000009882622
plcd4a / phospholipase C, delta 4a / PLCD4* / Q8K3R3* / Q9BRC7* / phospholipase C delta 4*ENSDARG0000005797521
plch1 / phospholipase C, eta 1 / Q4KWH5* / Q4KWH8* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 *ENSDARG0000007925321
plch2a / phospholipase C, eta 2a / PLCH2* / A2AP18* / O75038* / phospholipase C eta 2* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSDARG0000005996021
plcd1b / phospholipase C, delta 1b / PLCD1* / P51178* / phospholipase C delta 1*ENSDARG0000003408021
plcd3b / phospholipase C, delta 3b / PLCD3* / Q8N3E9* / Q8K2J0* / phospholipase C delta 3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSDARG0000007957220
plcd1a / phospholipase C, delta 1a / PLCD1* / Q8R3B1* / P51178* / phospholipase C delta 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 *ENSDARG0000005912320
plcd4b / phospholipase C, delta 4b / PLCD4* / Q8K3R3* / Q9BRC7* / phospholipase C delta 4*ENSDARG0000004068420
si:ch211-210g13.5ENSDARG0000006257520
PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *ENSDARG0000009038119
A5D6R3 / plcd3a / phospholipase C, delta 3a / PLCD3* / Q8N3E9* / Q8K2J0* / phospholipase C delta 3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSDARG0000005295719
plch2b / phospholipase C, eta 2b / PLCH2* / A2AP18* / O75038* / phospholipase C eta 2* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSDARG0000005680518
plcl1 / phospholipase C like 1 / Q15111* / Q3USB7* / phospholipase C like 1 (inactive)* / Inactive phospholipase C-like protein 1 *ENSDARG0000006767618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR009535  Phospholipase C-beta, conserved site
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000068246 plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*  / reaction
 ENSDARG00000090381 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / reaction
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / reaction / complex
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex
 ENSDARG00000100786 PLCB4 / phospholipase C beta 4 / Q15147*  / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / reaction / complex






 

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