ENSGALG00000008907


Gallus gallus

Features
Gene ID: ENSGALG00000008907
  
Biological name :PLCB4
  
Synonyms : phospholipase C beta 4 / PLCB4
  
Possible biological names infered from orthology : Q15147
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 13955750
Gene end: 14046844
  
Corresponding Affymetrix probe sets: GgaAffx.5604.1.S1_at (Chicken Array)   GgaAffx.5604.1.S1_s_at (Chicken Array)   GgaAffx.5604.2.S1_at (Chicken Array)   GgaAffx.5604.3.S1_at (Chicken Array)   GgaAffx.5604.4.S1_at (Chicken Array)   GgaAffx.5604.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000040699
NCBI entrez gene - 416730     See in Manteia.
RefSeq - XM_015283491
RefSeq - NM_001199435
RefSeq - XM_015283489
RefSeq - XM_015283490
RefSeq - XM_015283481
RefSeq - XM_015283483
RefSeq - XM_015283484
RefSeq - XM_015283485
RefSeq - XM_015283486
RefSeq - XM_015283487
RefSeq - XM_015283488
RefSeq Peptide - NP_001186364
swissprot - R4GFB3
Ensembl - ENSGALG00000008907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB4ENSDARG00000100786Danio rerio
 PLCB4ENSG00000101333Homo sapiens
 Plcb4ENSMUSG00000039943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCB1 / phospholipase C beta 1 / Q9NQ66* / Q9Z1B3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *ENSGALG0000000887539
PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *ENSGALG0000004210535
PLCL2 / phospholipase C like 2 / Q8K394* / Q9UPR0* / Inactive phospholipase C-like protein 2 *ENSGALG0000001124822
PLCH1 / phospholipase C eta 1 / Q4KWH5* / Q4KWH8* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 *ENSGALG0000001031222
PLCL1 / phospholipase C like 1 (inactive) / Q15111* / Q3USB7* / Inactive phospholipase C-like protein 1 *ENSGALG0000000811321
ENSGALG0000000334520
PLCD4 / phospholipase C delta 4 / Q8K3R3* / Q9BRC7*ENSGALG0000002668720
PLCD1 / phospholipase C delta 1 / P51178* / Q8R3B1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 *ENSGALG0000000580520
PLCH2 / phospholipase C eta 2 / A2AP18* / O75038* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSGALG0000000120719
PLCD3 / phospholipase C delta 3 / Q8K2J0* / Q8N3E9* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSGALG0000004521219
PLCZ1 / Q2VRL0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / Q8K4D7* / phospholipase C zeta 1*ENSGALG0000001312317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR009535  Phospholipase C-beta, conserved site
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008875 PLCB1 / phospholipase C beta 1 / Q9NQ66* / Q9Z1B3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *  / reaction
 ENSGALG00000015177 GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSGALG00000015176 GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSGALG00000008907 PLCB4 / phospholipase C beta 4 / Q15147*  / reaction
 ENSGALG00000042105 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / reaction






 

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