ENSGALG00000008875


Gallus gallus

Features
Gene ID: ENSGALG00000008875
  
Biological name :PLCB1
  
Synonyms : phospholipase C beta 1 / PLCB1
  
Possible biological names infered from orthology : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66 / Q9Z1B3
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 14197437
Gene end: 14580122
  
Corresponding Affymetrix probe sets: Gga.15452.1.S1_at (Chicken Array)   GgaAffx.22709.1.S1_at (Chicken Array)   GgaAffx.5569.1.S1_at (Chicken Array)   GgaAffx.5569.1.S1_s_at (Chicken Array)   GgaAffx.5573.1.S1_s_at (Chicken Array)   GgaAffx.5573.2.S1_at (Chicken Array)   GgaAffx.5573.2.S1_s_at (Chicken Array)   GgaAffx.5573.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045835
Ensembl peptide - ENSGALP00000014404
Ensembl peptide - ENSGALP00000049750
NCBI entrez gene - 427687     See in Manteia.
RefSeq - XM_015283582
swissprot - A0A1D5NZL7
swissprot - F1NLL3
Ensembl - ENSGALG00000008875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB1ENSDARG00000109726Danio rerio
 PLCB1ENSG00000182621Homo sapiens
 Plcb1ENSMUSG00000051177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *ENSGALG0000004210548
PLCB4 / phospholipase C beta 4 / Q15147*ENSGALG0000000890738
PLCL2 / phospholipase C like 2 / Q8K394* / Q9UPR0* / Inactive phospholipase C-like protein 2 *ENSGALG0000001124822
PLCL1 / phospholipase C like 1 (inactive) / Q15111* / Q3USB7* / Inactive phospholipase C-like protein 1 *ENSGALG0000000811321
PLCH1 / phospholipase C eta 1 / Q4KWH5* / Q4KWH8* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 *ENSGALG0000001031221
ENSGALG0000000334520
PLCD4 / phospholipase C delta 4 / Q8K3R3* / Q9BRC7*ENSGALG0000002668720
PLCD1 / phospholipase C delta 1 / P51178* / Q8R3B1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 *ENSGALG0000000580520
PLCH2 / phospholipase C eta 2 / A2AP18* / O75038* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSGALG0000000120719
PLCD3 / phospholipase C delta 3 / Q8K2J0* / Q8N3E9* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSGALG0000004521218
PLCZ1 / Q2VRL0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / Q8K4D7* / phospholipase C zeta 1*ENSGALG0000001312316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR009535  Phospholipase C-beta, conserved site
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028400  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007215 glutamate receptor signaling pathway IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway IEA
 biological_processGO:0035723 interleukin-15-mediated signaling pathway IEA
 biological_processGO:0040019 positive regulation of embryonic development IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048639 positive regulation of developmental growth IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060466 activation of meiosis involved in egg activation IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0080154 regulation of fertilization IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000344 positive regulation of acrosome reaction IEA
 biological_processGO:2000438 negative regulation of monocyte extravasation IEA
 biological_processGO:2000560 positive regulation of CD24 biosynthetic process IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0043209 myelin sheath IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005521 lamin binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002098 GRIK3 / glutamate ionotropic receptor kainate type subunit 3 / B1AS29* / Q13003* / Glutamate receptor ionotropic, kainate 3 *  / reaction / complex
 ENSGALG00000027629 GNG2 / G protein subunit gamma 2 / P59768* / P63213* / guanine nucleotide binding protein (G protein), gamma 2*  / complex / reaction
 ENSGALG00000015176 GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*  / reaction / complex
 ENSGALG00000008907 PLCB4 / phospholipase C beta 4 / Q15147*  / reaction
 ENSGALG00000008875 PLCB1 / phospholipase C beta 1 / Q9NQ66* / Q9Z1B3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *  / reaction
 ENSGALG00000001334 GNB1 / G protein subunit beta 1 / P62873* / P62874* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSGALG00000015177 GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex
 ENSGALG00000042105 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / reaction






 

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