ENSGALG00000042105


Gallus gallus

Features
Gene ID: ENSGALG00000042105
  
Biological name :PLCB2
  
Synonyms : phospholipase C beta 2 / PLCB2
  
Possible biological names infered from orthology : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / A3KGF7 / Q00722
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 622099
Gene end: 658176
  
Corresponding Affymetrix probe sets: GgaAffx.2978.1.S1_at (Chicken Array)   GgaAffx.2978.2.S1_s_at (Chicken Array)   GgaAffx.2978.3.S1_at (Chicken Array)   GgaAffx.2978.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050925
NCBI entrez gene - 423014     See in Manteia.
RefSeq - XM_015286275
RefSeq - XM_015286276
RefSeq - XM_420945
swissprot - A0A1D5PDS9
Ensembl - ENSGALG00000042105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB2ENSDARG00000090381Danio rerio
 PLCB2ENSG00000137841Homo sapiens
 Plcb2ENSMUSG00000040061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCB1 / phospholipase C beta 1 / Q9NQ66* / Q9Z1B3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *ENSGALG0000000887548
PLCB4 / phospholipase C beta 4 / Q15147*ENSGALG0000000890735
PLCL2 / phospholipase C like 2 / Q8K394* / Q9UPR0* / Inactive phospholipase C-like protein 2 *ENSGALG0000001124822
PLCH1 / phospholipase C eta 1 / Q4KWH5* / Q4KWH8* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 *ENSGALG0000001031222
ENSGALG0000000334520
PLCL1 / phospholipase C like 1 (inactive) / Q15111* / Q3USB7* / Inactive phospholipase C-like protein 1 *ENSGALG0000000811320
PLCD1 / phospholipase C delta 1 / P51178* / Q8R3B1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 *ENSGALG0000000580520
PLCH2 / phospholipase C eta 2 / A2AP18* / O75038* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSGALG0000000120718
PLCD3 / phospholipase C delta 3 / Q8K2J0* / Q8N3E9* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSGALG0000004521218
PLCD4 / phospholipase C delta 4 / Q8K3R3* / Q9BRC7*ENSGALG0000002668718
PLCZ1 / Q2VRL0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / Q8K4D7* / phospholipase C zeta 1*ENSGALG0000001312317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR009535  Phospholipase C-beta, conserved site
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028403  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050913 sensory perception of bitter taste IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002098 GRIK3 / glutamate ionotropic receptor kainate type subunit 3 / B1AS29* / Q13003* / Glutamate receptor ionotropic, kainate 3 *  / complex / reaction
 ENSGALG00000008875 PLCB1 / phospholipase C beta 1 / Q9NQ66* / Q9Z1B3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *  / reaction
 ENSGALG00000015177 GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSGALG00000015176 GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSGALG00000008907 PLCB4 / phospholipase C beta 4 / Q15147*  / reaction
 ENSGALG00000027629 GNG2 / G protein subunit gamma 2 / P59768* / P63213* / guanine nucleotide binding protein (G protein), gamma 2*  / complex / reaction
 ENSGALG00000001334 GNB1 / G protein subunit beta 1 / P62873* / P62874* / guanine nucleotide binding protein (G protein), beta 1*  / reaction / complex
 ENSGALG00000042105 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / reaction






 

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