ENSMUSG00000039943


Mus musculus

Features
Gene ID: ENSMUSG00000039943
  
Biological name :Plcb4
  
Synonyms : phospholipase C, beta 4 / Plcb4
  
Possible biological names infered from orthology : Q15147
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F3
Gene start: 135659011
Gene end: 136014593
  
Corresponding Affymetrix probe sets: 10476443 (MoGene1.0st)   1425338_at (Mouse Genome 430 2.0 Array)   1425339_at (Mouse Genome 430 2.0 Array)   1430871_at (Mouse Genome 430 2.0 Array)   1435771_at (Mouse Genome 430 2.0 Array)   1441531_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038409
Ensembl peptide - ENSMUSP00000117578
Ensembl peptide - ENSMUSP00000117638
Ensembl peptide - ENSMUSP00000139274
Ensembl peptide - ENSMUSP00000105736
NCBI entrez gene - 18798     See in Manteia.
MGI - MGI:107464
RefSeq - XM_017316414
RefSeq - XM_006498950
RefSeq - XM_006498951
RefSeq - XM_011239357
RefSeq - XM_011239358
RefSeq - XM_011239359
RefSeq - XM_017316368
RefSeq - NM_001355154
RefSeq - NM_013829
RefSeq - XM_006498936
RefSeq - XM_006498937
RefSeq - XM_006498938
RefSeq - XM_006498939
RefSeq - XM_006498940
RefSeq - XM_006498941
RefSeq - XM_006498942
RefSeq - XM_006498943
RefSeq - XM_006498944
RefSeq - XM_006498945
RefSeq - XM_006498946
RefSeq - XM_006498947
RefSeq - XM_006498948
RefSeq Peptide - NP_001342083
RefSeq Peptide - NP_038857
swissprot - A2AT93
swissprot - V9GXQ9
swissprot - A2AT91
swissprot - Q91UZ1
Ensembl - ENSMUSG00000039943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB4ENSDARG00000100786Danio rerio
 PLCB4ENSGALG00000008907Gallus gallus
 PLCB4ENSG00000101333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117739
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496037
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006134
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905523
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683423
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891022
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834921
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617321
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066020
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093719
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR009535  Phospholipase C-beta, conserved site
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0030425 dendrite IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040061 Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*  / reaction
 ENSMUSG00000024960 Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*  / reaction
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / complex / reaction
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / complex / reaction
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / complex / reaction
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000051177 Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*  / reaction
 ENSMUSG00000039943 Plcb4 / phospholipase C, beta 4 / Q15147*  / reaction






 

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