ENSMUSG00000029055


Mus musculus

Features
Gene ID: ENSMUSG00000029055
  
Biological name :Plch2
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / A2AP18 / Plch2
  
Possible biological names infered from orthology : O75038 / phospholipase C eta 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 154983115
Gene end: 155056784
  
Corresponding Affymetrix probe sets: 10519069 (MoGene1.0st)   1436335_at (Mouse Genome 430 2.0 Array)   1441587_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134750
Ensembl peptide - ENSMUSP00000122704
Ensembl peptide - ENSMUSP00000135209
Ensembl peptide - ENSMUSP00000141152
Ensembl peptide - ENSMUSP00000101256
Ensembl peptide - ENSMUSP00000115440
Ensembl peptide - ENSMUSP00000118292
Ensembl peptide - ENSMUSP00000118629
Ensembl peptide - ENSMUSP00000119864
Ensembl peptide - ENSMUSP00000122139
NCBI entrez gene - 269615     See in Manteia.
MGI - MGI:2443078
RefSeq - XM_017320247
RefSeq - XM_006538944
RefSeq - XM_011250268
RefSeq - XM_011250269
RefSeq - XM_011250270
RefSeq - XM_011250271
RefSeq - XM_011250272
RefSeq - XM_011250273
RefSeq - XM_011250274
RefSeq - XM_011250275
RefSeq - XM_011250276
RefSeq - NM_001113360
RefSeq - NM_175556
RefSeq - XM_006538936
RefSeq - XM_006538940
RefSeq Peptide - NP_780765
RefSeq Peptide - NP_001106831
swissprot - F7C3A0
swissprot - F7C512
swissprot - H3BIW6
swissprot - A6PWW4
swissprot - A2AP18
swissprot - A0A087WSR3
swissprot - H3BK11
swissprot - F6UKG4
Ensembl - ENSMUSG00000029055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plch2aENSDARG00000059960Danio rerio
 plch2bENSDARG00000056805Danio rerio
 PLCH2ENSGALG00000001207Gallus gallus
 PLCH2ENSG00000149527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683447
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834923
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891023
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066020
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496019
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093719
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117719
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617319
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994318
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006118
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028392  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
 IPR028393  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IDA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050429 calcium-dependent phospholipase C activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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