ENSDARG00000057975


Danio rerio

Features
Gene ID: ENSDARG00000057975
  
Biological name :plcd4a
  
Synonyms : phospholipase C, delta 4a / plcd4a
  
Possible biological names infered from orthology : phospholipase C delta 4 / PLCD4 / Q8K3R3 / Q9BRC7
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 12729329
Gene end: 12746539
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000115303
Ensembl peptide - ENSDARP00000143390
NCBI entrez gene - 565669     See in Manteia.
swissprot - F1Q5G9
swissprot - F1Q876
ZFIN ID - ZDB-GENE-050208-654
Ensembl - ENSDARG00000057975
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCD4ENSGALG00000026687Gallus gallus
 PLCD4ENSG00000115556Homo sapiens
 Plcd4ENSMUSG00000026173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plcd4b / phospholipase C, delta 4b / PLCD4* / Q8K3R3* / Q9BRC7* / phospholipase C delta 4*ENSDARG0000004068466
plcd1b / phospholipase C, delta 1b / PLCD1* / P51178* / phospholipase C delta 1*ENSDARG0000003408049
plcd3b / phospholipase C, delta 3b / PLCD3* / Q8N3E9* / Q8K2J0* / phospholipase C delta 3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSDARG0000007957249
plcd1a / phospholipase C, delta 1a / PLCD1* / Q8R3B1* / P51178* / phospholipase C delta 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 *ENSDARG0000005912349
A5D6R3 / plcd3a / phospholipase C, delta 3a / PLCD3* / Q8N3E9* / Q8K2J0* / phospholipase C delta 3* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 *ENSDARG0000005295749
plch1 / phospholipase C, eta 1 / Q4KWH5* / Q4KWH8* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 *ENSDARG0000007925342
plch2a / phospholipase C, eta 2a / PLCH2* / A2AP18* / O75038* / phospholipase C eta 2* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSDARG0000005996042
si:ch211-210g13.5ENSDARG0000006257539
plcl2 / phospholipase C like 2 / Q8K394* / Q9UPR0* / Inactive phospholipase C-like protein 2 *ENSDARG0000009882639
plcl1 / phospholipase C like 1 / Q15111* / Q3USB7* / phospholipase C like 1 (inactive)* / Inactive phospholipase C-like protein 1 *ENSDARG0000006767634
plch2b / phospholipase C, eta 2b / PLCH2* / A2AP18* / O75038* / phospholipase C eta 2* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 *ENSDARG0000005680534
plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*ENSDARG0000006824631
PLCB4 / phospholipase C beta 4 / Q15147*ENSDARG0000010078631
PLCB1 / si:ch1073-140o9.2 / Q9NQ66* / Q9Z1B3* / phospholipase C beta 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 *ENSDARG0000010972620
PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *ENSDARG0000009038116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028387  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway IGI
 biological_processGO:0007340 acrosome reaction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:1901232 regulation of convergent extension involved in axis elongation IGI
 biological_processGO:1904088 positive regulation of epiboly involved in gastrulation with mouth forming second IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030695 GTPase regulator activity IDA
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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