ENSDARG00000056831


Danio rerio

Features
Gene ID: ENSDARG00000056831
  
Biological name :gng2
  
Synonyms : gng2 / guanine nucleotide binding protein (G protein), gamma 2
  
Possible biological names infered from orthology : G protein subunit gamma 2 / P59768 / P63213
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 12045475
Gene end: 12088835
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133645
Ensembl peptide - ENSDARP00000136759
Ensembl peptide - ENSDARP00000073854
Ensembl peptide - ENSDARP00000130653
Ensembl peptide - ENSDARP00000132128
Ensembl peptide - ENSDARP00000132424
NCBI entrez gene - 550256     See in Manteia.
RefSeq - NM_001044318
RefSeq - XM_021480572
RefSeq Peptide - NP_001037783
RefSeq Peptide - NP_001333203
RefSeq Peptide - NP_001333204
swissprot - A0A0R4ILA3
swissprot - Q15KE4
ZFIN ID - ZDB-GENE-050417-59
Ensembl - ENSDARG00000056831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNG2ENSGALG00000027629Gallus gallus
 GNG2ENSG00000186469Homo sapiens
 Gng2ENSMUSG00000043004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNG4 / G protein subunit gamma 4 / P50150*ENSDARG0000011125980
gng3 / guanine nucleotide binding protein (G protein), gamma 3 / P63215* / P63216* / G protein subunit gamma 3*ENSDARG0000000955373
gng8 / guanine nucleotide binding protein (G protein), gamma 8 / P63078* / Q9UK08* / G protein subunit gamma 8*ENSDARG0000004297070
gng7 / guanine nucleotide binding protein (G protein), gamma 7 / O60262* / Q61016* / G protein subunit gamma 7*ENSDARG0000003869368
si:dkey-44g17.6 / GNG12* / Q9DAS9* / Q9UBI6* / G protein subunit gamma 12* / guanine nucleotide binding protein (G protein), gamma 12*ENSDARG0000009812359
gng12a / guanine nucleotide binding protein (G protein), gamma 12a / GNG12* / Q9UBI6* / Q9DAS9* / G protein subunit gamma 12* / guanine nucleotide binding protein (G protein), gamma 12*ENSDARG0000000337555
gng10 / guanine nucleotide binding protein (G protein), gamma 10 / P50151* / G protein subunit gamma 10*ENSDARG0000010404346
GNG14 / si:dkey-117i10.1 / Gm5741* / A0A1W2PPG7* / G protein subunit gamma 14*ENSDARG0000006253745
gng5 / guanine nucleotide binding protein (G protein), gamma 5 / P63218* / Q80SZ7* / G protein subunit gamma 5*ENSDARG0000003983045
si:ch211-286b5.5ENSDARG0000009666144
si:dkey-204f11.64ENSDARG0000009469542


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IGI
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
G-protein activation
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000024101 adra1d / adrenoceptor alpha 1D / P25100*  / complex / reaction
 ENSDARG00000011317 adra1ba / adrenoceptor alpha 1Ba / ADRA1B* / P35368* / adrenoceptor alpha 1B*  / complex / reaction
 ENSDARG00000036058 gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...  / complex
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / reaction / complex
 ENSDARG00000025826 gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*  / complex / reaction
 ENSDARG00000028725 adra1aa / adrenoceptor alpha 1Aa / ADRA1A* / P35348* / adrenoceptor alpha 1A*  / complex / reaction
 ENSDARG00000044861 Q8AYN0 / opn1lw2 / opsin 1 (cone pigments), long-wave-sensitive, 2 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / complex / reaction
 ENSDARG00000044199 gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...  / complex
 ENSDARG00000042529 gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...  / complex
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / reaction / complex
 ENSDARG00000040841 adra2a / adrenoceptor alpha 2A / P08913*  / complex / reaction
 ENSDARG00000043135 pomca / proopiomelanocortin a / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / complex / reaction
 ENSDARG00000039434 oprm1 / opioid receptor, mu 1 / P35372* / P42866*  / complex / reaction
 ENSDARG00000044862 Q9W6A7 / opn1lw1 / opsin 1 (cone pigments), long-wave-sensitive, 1 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / reaction / complex
 ENSDARG00000027638 adra1ab / adrenoceptor alpha 1Ab / ADRA1A* / P35348* / P97718* / adrenoceptor alpha 1A* / Alpha-1A adrenergic receptor *  / reaction / complex
 ENSDARG00000079472 CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*  / reaction / complex
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / reaction
 ENSDARG00000035357 gnb2 / guanine nucleotide binding protein (G protein), beta polypeptide 2 / P62880* / P62879* / G protein subunit beta 2* / guanine nucleotide binding protein (G protein), beta 2*  / complex / reaction
 ENSDARG00000069307 pomcb / proopiomelanocortin b / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / complex / reaction
 ENSDARG00000079399 F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*  / reaction / complex
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSDARG00000038278 ptgir / prostaglandin I2 receptor / P43119* / P43252* / Prostacyclin receptor *  / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSDARG00000087798 pdyn / prodynorphin / P01213*  / reaction / complex
 ENSDARG00000030644 gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...  / reaction / complex
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / complex / reaction
 ENSDARG00000017294 gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...  / complex / reaction
 ENSDARG00000004358 gnb3a / guanine nucleotide binding protein (G protein), beta polypeptide 3a / GNB3* / Q61011* / P16520* / G protein subunit beta 3* / guanine nucleotide binding protein (G protein), beta 3*  / complex / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSDARG00000009480 pdcl / phosducin-like / Q13371* / Q9DBX2* / Phosducin-like protein *  / reaction / complex
 ENSDARG00000069669 adra2c / Q90WY6 / adrenoceptor alpha 2C / P18825* / Q01337* / Alpha-2C adrenergic receptor *  / reaction / complex
 ENSDARG00000002696 gnb3b / guanine nucleotide binding protein (G protein), beta polypeptide 3b / GNB3* / Q61011* / P16520* / G protein subunit beta 3* / guanine nucleotide binding protein (G protein), beta 3*  / complex / reaction
 ENSDARG00000018174 gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...  / reaction / complex
 ENSDARG00000073765 gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*  / complex / reaction
 ENSDARG00000090524 f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*  / complex / reaction
 ENSDARG00000115383 gnb4b / guanine nucleotide binding protein (G protein), beta polypeptide 4b / GNB4* / Q9HAV0* / G protein subunit beta 4*  / complex / reaction
 ENSDARG00000069945 p2ry12 / purinergic receptor P2Y12 / Q9CPV9* / Q9H244* / purinergic receptor P2Y, G-protein coupled 12*  / complex / reaction
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / reaction / complex
 ENSDARG00000068246 plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*  / reaction / complex
 ENSDARG00000090381 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / complex / reaction
 ENSDARG00000016676 gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...  / complex
 ENSDARG00000091140 pik3r6b / phosphoinositide-3-kinase, regulatory subunit 6b / PIK3R6* / Q5UE93* / Q3U6Q4* / phosphoinositide-3-kinase regulatory subunit 6*  / complex / reaction
 ENSDARG00000105281 p2ry1 / purinergic receptor P2Y1 / P47900* / P49650* / purinergic receptor P2Y, G-protein coupled 1*  / complex
 ENSDARG00000102762 pik3r5 / phosphoinositide-3-kinase, regulatory subunit 5 / Q5SW28* / Q8WYR1*  / reaction / complex
 ENSDARG00000099844 GNAZ / G protein subunit alpha z / P19086*  / complex / reaction






 

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