ENSDARG00000043135


Danio rerio

Features
Gene ID: ENSDARG00000043135
  
Biological name :pomca
  
Synonyms : pomca / proopiomelanocortin a
  
Possible biological names infered from orthology : P01189 / P01193 / POMC / proopiomelanocortin / pro-opiomelanocortin-alpha
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 33226955
Gene end: 33230039
  
Corresponding Affymetrix probe sets: Dr.19934.1.S1_s_at (Zebrafish Array)   NM_181438_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000063332
NCBI entrez gene - 353221     See in Manteia.
RefSeq - NM_181438
RefSeq Peptide - NP_852103
swissprot - Q7ZT18
ZFIN ID - ZDB-GENE-030513-2
Ensembl - ENSDARG00000043135
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 POMCENSGALG00000016600Gallus gallus
 POMCENSG00000115138Homo sapiens
 PomcENSMUSG00000020660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pomcb / proopiomelanocortin b / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*ENSDARG0000006930737


Protein motifs (from Interpro)
Interpro ID Name
 IPR001941  Pro-opiomelanocortin
 IPR013531  Pro-opiomelanocortin/corticotropin, ACTH, central region
 IPR013532  Opiodes neuropeptide
 IPR013593  Pro-opiomelanocortin N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032400 melanosome localization IMP
 biological_processGO:0033555 multicellular organismal response to stress IEP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IGI
 biological_processGO:2000852 regulation of corticosterone secretion IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IDA


Pathways (from Reactome)
Pathway description
Opioid Signalling
Androgen biosynthesis
Glucocorticoid biosynthesis
G-protein activation
Peptide hormone biosynthesis
Endogenous sterols
Peptide ligand-binding receptors
G alpha (s) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009091 melanocyte melanocyte melanosome aggregated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002600 pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *  / reaction
 ENSDARG00000021369 mc3r / melanocortin 3 receptor / P33033* / P41968* / Melanocortin receptor 3 *  / complex / reaction
 ENSDARG00000015515 mc4r / B0V1P1 / melanocortin 4 receptor / P32245* / P56450* / Melanocortin receptor 4 *  / complex / reaction
 ENSDARG00000031348 mc5ra / melanocortin 5a receptor / MC5R* / P33032* / melanocortin 5 receptor*  / complex / reaction
 ENSDARG00000054946 mc5rb / melanocortin 5b receptor / MC5R* / P33032* / melanocortin 5 receptor*  / complex / reaction
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSDARG00000054949 mc2r / melanocortin 2 receptor / Q01718* / Q64326*  / reaction / complex
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000039434 oprm1 / opioid receptor, mu 1 / P35372* / P42866*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr