ENSDARG00000002600


Danio rerio

Features
Gene ID: ENSDARG00000002600
  
Biological name :pcsk1
  
Synonyms : pcsk1 / proprotein convertase subtilisin/kexin type 1
  
Possible biological names infered from orthology : Neuroendocrine convertase 1 / P29120 / P63239
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 11684830
Gene end: 11722343
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000004083
Ensembl peptide - ENSDARP00000118568
NCBI entrez gene - 100005716     See in Manteia.
RefSeq - NM_001137662
RefSeq Peptide - NP_001131134
swissprot - E9QIE6
swissprot - B6VCA1
ZFIN ID - ZDB-GENE-071009-1
Ensembl - ENSDARG00000002600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PCSK1ENSGALG00000014681Gallus gallus
 PCSK1ENSG00000175426Homo sapiens
 Pcsk1ENSMUSG00000021587Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000007097141
furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000006290941
pcsk5a / proprotein convertase subtilisin/kexin type 5a / PCSK5* / Q92824* / Q04592* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006753739
pcsk2 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSDARG0000001945136
pcsk7 / proprotein convertase subtilisin/kexin type 7 / Q16549*ENSDARG0000006996831
pcsk5b / proprotein convertase subtilisin/kexin type 5b / PCSK5* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006051829
pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSDARG0000010457413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022005  Prohormone convertase enzyme
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Peptide hormone biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000043135 pomca / proopiomelanocortin a / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / reaction
 ENSDARG00000069307 pomcb / proopiomelanocortin b / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / reaction






 

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