ENSGALG00000014681


Gallus gallus

Features
Gene ID: ENSGALG00000014681
  
Biological name :PCSK1
  
Synonyms : PCSK1 / proprotein convertase subtilisin/kexin type 1
  
Possible biological names infered from orthology : Neuroendocrine convertase 1 / P29120 / P63239
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 57130825
Gene end: 57158645
  
Corresponding Affymetrix probe sets: Gga.9357.1.S1_at (Chicken Array)   GgaAffx.9299.1.S1_at (Chicken Array)   GgaAffx.9299.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023612
Ensembl peptide - ENSGALP00000045142
NCBI entrez gene - 769230     See in Manteia.
RefSeq - XM_003643060
swissprot - A0A1D5NXP3
swissprot - F1NB95
Ensembl - ENSGALG00000014681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk1ENSDARG00000002600Danio rerio
 PCSK1ENSG00000175426Homo sapiens
 Pcsk1ENSMUSG00000021587Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*ENSGALG0000000834143
PCSK6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSGALG0000003007640
PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSGALG0000003325639
PCSK2 / proprotein convertase subtilisin/kexin type 2 / P16519* / P21661*ENSGALG0000000873437
PCSK4 / proprotein convertase subtilisin/kexin type 4 / P29121* / Q6UW60*ENSGALG0000002638434
PCSK7 / proprotein convertase subtilisin/kexin type 7 / Q16549* / Q61139*ENSGALG0000002922032
PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSGALG000000151642


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022005  Prohormone convertase enzyme
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016486 peptide hormone processing IEA
 biological_processGO:0043043 peptide biosynthetic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Peptide hormone biosynthesis
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008411 GHRL / appetite-regulating hormone preproprotein / Q9EQX0* / Q9UBU3* / ghrelin and obestatin prepropeptide* / Appetite-regulating hormone Ghrelin Obestatin*  / reaction
 ENSGALG00000016600 POMC / pro-opiomelanocortin precursor / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / reaction






 

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