ENSGALG00000008411


Gallus gallus

Features
Gene ID: ENSGALG00000008411
  
Biological name :GHRL
  
Synonyms : appetite-regulating hormone preproprotein / GHRL
  
Possible biological names infered from orthology : Appetite-regulating hormone Ghrelin Obestatin / ghrelin and obestatin prepropeptide / Q9EQX0 / Q9UBU3
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 19487356
Gene end: 19490057
  
Corresponding Affymetrix probe sets: Gga.16.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013685
NCBI entrez gene - 408185     See in Manteia.
RefSeq - NM_001001131
RefSeq - XM_015293041
RefSeq Peptide - NP_001001131
swissprot - Q8AV73
Ensembl - ENSGALG00000008411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GHRLENSG00000157017Homo sapiens
 GhrlENSMUSG00000064177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005441  Preproghrelin peptide
 IPR006737  Motilin/ghrelin-associated peptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001696 gastric acid secretion IBA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0006939 smooth muscle contraction IMP
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0032099 negative regulation of appetite IDA
 biological_processGO:0032100 positive regulation of appetite IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IEA
 biological_processGO:0040013 negative regulation of locomotion IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep IEA
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion IEA
 biological_processGO:0051464 positive regulation of cortisol secretion IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IBA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IMP
 biological_processGO:2000854 positive regulation of corticosterone secretion IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0016608 growth hormone-releasing hormone activity IBA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031768 ghrelin receptor binding IMP


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014681 PCSK1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *  / reaction
 ENSGALG00000016713 PLA2G7 / platelet-activating factor acetylhydrolase precursor / Q60963* / Q13093* / phospholipase A2 group VII* / Platelet-activating factor acetylhydrolase *  / reaction
 ENSGALG00000011454 MBOAT4 / membrane bound O-acyltransferase domain containing 4 / P0C7A3* / Q96T53* / Ghrelin O-acyltransferase *  / reaction
 ENSGALG00000034860 BCHE / cholinesterase precursor / P06276* / Q03311* / Cholinesterase * / butyrylcholinesterase*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr