ENSG00000157017


Homo sapiens

Features
Gene ID: ENSG00000157017
  
Biological name :GHRL
  
Synonyms : ghrelin and obestatin prepropeptide / GHRL / Q9UBU3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.3
Gene start: 10285675
Gene end: 10292947
  
Corresponding Affymetrix probe sets: 223862_at (Human Genome U133 Plus 2.0 Array)   237647_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405464
Ensembl peptide - ENSP00000405031
Ensembl peptide - ENSP00000414819
Ensembl peptide - ENSP00000416768
Ensembl peptide - ENSP00000287656
Ensembl peptide - ENSP00000335074
Ensembl peptide - ENSP00000388145
Ensembl peptide - ENSP00000391406
Ensembl peptide - ENSP00000394923
Ensembl peptide - ENSP00000399922
Ensembl peptide - ENSP00000403725
NCBI entrez gene - 51738     See in Manteia.
OMIM - 605353
RefSeq - XM_017006613
RefSeq - NM_001134941
RefSeq - NM_001134944
RefSeq - NM_001134945
RefSeq - NM_001134946
RefSeq - NM_001302821
RefSeq - NM_001302822
RefSeq - NM_001302823
RefSeq - NM_001302824
RefSeq - NM_001302825
RefSeq - NM_016362
RefSeq - XM_017006612
RefSeq Peptide - NP_001128413
RefSeq Peptide - NP_001128416
RefSeq Peptide - NP_001289753
RefSeq Peptide - NP_001289754
RefSeq Peptide - NP_057446
RefSeq Peptide - NP_001128417
RefSeq Peptide - NP_001128418
RefSeq Peptide - NP_001289750
RefSeq Peptide - NP_001289751
RefSeq Peptide - NP_001289752
swissprot - E7ESW0
swissprot - Q9UBU3
swissprot - A8DN24
Ensembl - ENSG00000157017
  
Related genetic diseases (OMIM): 601665 - {Obesity, susceptibility to}, 601665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GHRLENSGALG00000008411Gallus gallus
 GhrlENSMUSG00000064177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005441  Preproghrelin peptide
 IPR006737  Motilin/ghrelin-associated peptide
 IPR006738  Motilin/ghrelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001696 gastric acid secretion IBA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0006006 glucose metabolic process NAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0008154 actin polymerization or depolymerization IDA
 biological_processGO:0008343 adult feeding behavior ISS
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0009755 hormone-mediated signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016358 dendrite development IDA
 biological_processGO:0016525 negative regulation of angiogenesis NAS
 biological_processGO:0030252 growth hormone secretion TAS
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032024 positive regulation of insulin secretion ISS
 biological_processGO:0032095 regulation of response to food IBA
 biological_processGO:0032097 positive regulation of response to food IEA
 biological_processGO:0032100 positive regulation of appetite ISS
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IDA
 biological_processGO:0035483 gastric emptying IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0040010 positive regulation of growth rate IEA
 biological_processGO:0040013 negative regulation of locomotion IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IC
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep IDA
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043400 cortisol secretion NAS
 biological_processGO:0043627 response to estrogen IDA
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process IDA
 biological_processGO:0045927 positive regulation of growth IEA
 biological_processGO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IDA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046697 decidualization IDA
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0051216 cartilage development NAS
 biological_processGO:0051461 positive regulation of corticotropin secretion IDA
 biological_processGO:0051464 positive regulation of cortisol secretion IDA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0051969 regulation of transmission of nerve impulse IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion IDA
 biological_processGO:0060399 positive regulation of growth hormone receptor signaling pathway IC
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0120058 positive regulation of small intestinal transit IEA
 biological_processGO:1903012 positive regulation of bone development IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1904000 positive regulation of eating behavior IEA
 biological_processGO:1904179 positive regulation of adipose tissue development IEA
 biological_processGO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction IEA
 biological_processGO:1904346 positive regulation of gastric mucosal blood circulation IEA
 biological_processGO:1904349 positive regulation of small intestine smooth muscle contraction IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905333 regulation of gastric motility IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000253 positive regulation of feeding behavior IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding ISS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016608 growth hormone-releasing hormone activity IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IMP
 molecular_functionGO:0031768 ghrelin receptor binding TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121853 GHSR / Q92847 / growth hormone secretagogue receptor  / reaction / complex
 ENSG00000114200 BCHE / P06276 / butyrylcholinesterase  / reaction
 ENSG00000175426 PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1  / reaction
 ENSG00000146070 PLA2G7 / Q13093 / phospholipase A2 group VII  / reaction
 ENSG00000177669 MBOAT4 / Q96T53 / membrane bound O-acyltransferase domain containing 4  / reaction






 

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