ENSG00000114200


Homo sapiens

Features
Gene ID: ENSG00000114200
  
Biological name :BCHE
  
Synonyms : BCHE / butyrylcholinesterase / P06276
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q26.1
Gene start: 165772904
Gene end: 165837472
  
Corresponding Affymetrix probe sets: 205433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418325
Ensembl peptide - ENSP00000419505
Ensembl peptide - ENSP00000419804
Ensembl peptide - ENSP00000264381
Ensembl peptide - ENSP00000418504
NCBI entrez gene - 590     See in Manteia.
OMIM - 177400
RefSeq - XM_017006967
RefSeq - NM_000055
RefSeq Peptide - NP_000046
swissprot - H0Y885
swissprot - H7C4Y0
swissprot - F8WEX7
swissprot - P06276
swissprot - F8WF14
Ensembl - ENSG00000114200
  
Related genetic diseases (OMIM): 617936 - Butyrylcholinesterase deficiency, 617936
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCHEENSGALG00000034860Gallus gallus
 BcheENSMUSG00000027792Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACHE / P22303 / acetylcholinesterase (Cartwright blood group)ENSG0000008708548
NLGN3 / Q9NZ94 / neuroligin 3ENSG0000019633835
NLGN2 / Q8NFZ4 / neuroligin 2ENSG0000016999233
NLGN4X / Q8N0W4 / neuroligin 4, X-linkedENSG0000014693833
NLGN1 / Q8N2Q7 / neuroligin 1ENSG0000016976033
NLGN4Y / Q8NFZ3 / neuroligin 4, Y-linkedENSG0000016524633
CES2 / O00748 / carboxylesterase 2ENSG0000017283131
CES1 / P23141 / carboxylesterase 1ENSG0000019884830
CES5A / Q6NT32 / carboxylesterase 5AENSG0000015939830
CES3 / Q6UWW8 / carboxylesterase 3ENSG0000017282828
CEL / carboxyl ester lipaseENSG0000017083528
CES4A / Q5XG92 / carboxylesterase 4AENSG0000017282424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000997  Cholinesterase
 IPR002018  Carboxylesterase, type B
 IPR014788  Acetylcholinesterase, tetramerisation domain
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014016 neuroblast differentiation IEA
 biological_processGO:0019695 choline metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0050783 cocaine metabolic process TAS
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051593 response to folic acid IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005641 nuclear envelope lumen IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0001540 amyloid-beta binding NAS
 molecular_functionGO:0003824 catalytic activity NAS
 molecular_functionGO:0003990 acetylcholinesterase activity IEA
 molecular_functionGO:0004104 cholinesterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds TAS
 molecular_functionGO:0019899 enzyme binding NAS
 molecular_functionGO:0033265 choline binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter clearance
Synthesis of PC
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157017 GHRL / Q9UBU3 / ghrelin and obestatin prepropeptide  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr