ENSG00000169760


Homo sapiens

Features
Gene ID: ENSG00000169760
  
Biological name :NLGN1
  
Synonyms : neuroligin 1 / NLGN1 / Q8N2Q7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.31
Gene start: 173396284
Gene end: 174286644
  
Corresponding Affymetrix probe sets: 205893_at (Human Genome U133 Plus 2.0 Array)   231361_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392500
Ensembl peptide - ENSP00000385750
Ensembl peptide - ENSP00000401843
Ensembl peptide - ENSP00000410374
Ensembl peptide - ENSP00000407255
Ensembl peptide - ENSP00000354541
NCBI entrez gene - 22871     See in Manteia.
OMIM - 600568
RefSeq - XM_017005905
RefSeq - XM_017005899
RefSeq - XM_017005900
RefSeq - XM_017005901
RefSeq - XM_017005902
RefSeq - XM_017005903
RefSeq - XM_017005904
RefSeq - NM_014932
RefSeq - XM_005247234
RefSeq - XM_005247235
RefSeq - XM_005247236
RefSeq - XM_005247237
RefSeq - XM_006713540
RefSeq - XM_011512551
RefSeq - XM_011512552
RefSeq - XM_011512553
RefSeq - XM_011512554
RefSeq - XM_017005888
RefSeq - XM_017005889
RefSeq - XM_017005890
RefSeq - XM_017005891
RefSeq - XM_017005892
RefSeq - XM_017005893
RefSeq - XM_017005894
RefSeq - XM_017005895
RefSeq - XM_017005896
RefSeq - XM_017005897
RefSeq - XM_017005898
RefSeq Peptide - NP_055747
swissprot - C9JWG7
swissprot - C9J4D3
swissprot - J3KQ19
swissprot - A0A1D5RMP7
swissprot - Q8N2Q7
Ensembl - ENSG00000169760
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn1ENSDARG00000077710Danio rerio
 NLGN1ENSGALG00000040938Gallus gallus
 Nlgn1ENSMUSG00000063887Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLGN4X / Q8N0W4 / neuroligin 4, X-linkedENSG0000014693872
NLGN4Y / Q8NFZ3 / neuroligin 4, Y-linkedENSG0000016524671
NLGN3 / Q9NZ94 / neuroligin 3ENSG0000019633868
NLGN2 / Q8NFZ4 / neuroligin 2ENSG0000016999264
CEL / carboxyl ester lipaseENSG0000017083526
ACHE / P22303 / acetylcholinesterase (Cartwright blood group)ENSG0000008708525
BCHE / P06276 / butyrylcholinesteraseENSG0000011420024
CES1 / P23141 / carboxylesterase 1ENSG0000019884822
CES2 / O00748 / carboxylesterase 2ENSG0000017283122
CES5A / Q6NT32 / carboxylesterase 5AENSG0000015939822
CES3 / Q6UWW8 / carboxylesterase 3ENSG0000017282822
CES4A / Q5XG92 / carboxylesterase 4AENSG0000017282417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030022  Neuroligin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA
 biological_processGO:0006605 protein targeting ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
 biological_processGO:0007158 neuron cell-cell adhesion NAS
 biological_processGO:0007399 nervous system development ISS
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness ISS
 biological_processGO:0016080 synaptic vesicle targeting ISS
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
 biological_processGO:0023041 neuronal signal transduction TAS
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic ISS
 biological_processGO:0035418 protein localization to synapse ISS
 biological_processGO:0045184 establishment of protein localization ISS
 biological_processGO:0045664 regulation of neuron differentiation ISS
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048489 synaptic vesicle transport IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048789 cytoskeletal matrix organization at active zone ISS
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development ISS
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IGI
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0072553 terminal button organization ISS
 biological_processGO:0097091 synaptic vesicle clustering ISS
 biological_processGO:0097104 postsynaptic membrane assembly IBA
 biological_processGO:0097105 presynaptic membrane assembly IBA
 biological_processGO:0097113 AMPA glutamate receptor clustering ISS
 biological_processGO:0097114 NMDA glutamate receptor clustering ISS
 biological_processGO:0097115 neurexin clustering involved in presynaptic membrane assembly ISS
 biological_processGO:0097119 postsynaptic density protein 95 clustering ISS
 biological_processGO:0097120 receptor localization to synapse ISS
 biological_processGO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex IEA
 biological_processGO:0099054 presynapse assembly TAS
 biological_processGO:0099560 synaptic membrane adhesion IEA
 biological_processGO:0140058 neuron projection arborization ISS
 biological_processGO:1900029 positive regulation of ruffle assembly ISS
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis ISS
 biological_processGO:1902474 positive regulation of protein localization to synapse IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction ISS
 biological_processGO:1904861 excitatory synapse assembly ISS
 biological_processGO:1905520 positive regulation of presynaptic active zone assembly IEA
 biological_processGO:2000302 positive regulation of synaptic vesicle exocytosis ISS
 biological_processGO:2000310 regulation of NMDA receptor activity IGI
 biological_processGO:2000311 regulation of AMPA receptor activity ISS
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0014069 postsynaptic density TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032433 filopodium tip ISS
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0089717 spanning component of membrane TAS
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse NAS
 cellular_componentGO:0098985 asymmetric, glutamatergic, excitatory synapse TAS
 cellular_componentGO:0099055 integral component of postsynaptic membrane TAS
 molecular_functionGO:0001540 amyloid-beta binding NAS
 molecular_functionGO:0030165 PDZ domain binding IDA
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0046983 protein dimerization activity ISS
 molecular_functionGO:0050839 cell adhesion molecule binding ISS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA
 molecular_functionGO:0097110 scaffold protein binding IDA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169760 NLGN1 / Q8N2Q7 / neuroligin 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr