ENSG00000165246


Homo sapiens

Features
Gene ID: ENSG00000165246
  
Biological name :NLGN4Y
  
Synonyms : neuroligin 4, Y-linked / NLGN4Y / Q8NFZ3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: Y
Strand: 1
Band: q11.221
Gene start: 14522573
Gene end: 14845650
  
Corresponding Affymetrix probe sets: 1554125_a_at (Human Genome U133 Plus 2.0 Array)   207703_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000372325
Ensembl peptide - ENSP00000372320
Ensembl peptide - ENSP00000412638
Ensembl peptide - ENSP00000496594
Ensembl peptide - ENSP00000494046
Ensembl peptide - ENSP00000342535
Ensembl peptide - ENSP00000348169
NCBI entrez gene - 22829     See in Manteia.
OMIM - 400028
RefSeq - XM_017030041
RefSeq - XM_011531430
RefSeq - XM_017030034
RefSeq - XM_017030035
RefSeq - XM_017030036
RefSeq - XM_017030037
RefSeq - XM_017030038
RefSeq - XM_017030039
RefSeq - XM_017030040
RefSeq - NM_001164238
RefSeq - NM_001206850
RefSeq - NM_014893
RefSeq - XM_006724874
RefSeq - XM_011531424
RefSeq - XM_011531425
RefSeq - XM_011531426
RefSeq - XM_011531427
RefSeq - XM_011531428
RefSeq - XM_011531429
RefSeq Peptide - NP_055708
RefSeq Peptide - NP_001157710
RefSeq Peptide - NP_001193779
swissprot - B4DHI3
swissprot - A0A024R9E7
swissprot - Q8NFZ3
swissprot - A6NMU8
swissprot - H0Y7G6
Ensembl - ENSG00000165246
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn4aENSDARG00000079455Danio rerio
 nlgn4bENSDARG00000077761Danio rerio
 NLGN4LENSGALG00000016628Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLGN4X / Q8N0W4 / neuroligin 4, X-linkedENSG0000014693898
NLGN1 / Q8N2Q7 / neuroligin 1ENSG0000016976072
NLGN3 / Q9NZ94 / neuroligin 3ENSG0000019633872
NLGN2 / Q8NFZ4 / neuroligin 2ENSG0000016999263
ACHE / P22303 / acetylcholinesterase (Cartwright blood group)ENSG0000008708525
CEL / carboxyl ester lipaseENSG0000017083525
BCHE / P06276 / butyrylcholinesteraseENSG0000011420024
CES2 / O00748 / carboxylesterase 2ENSG0000017283122
CES5A / Q6NT32 / carboxylesterase 5AENSG0000015939822
CES1 / P23141 / carboxylesterase 1ENSG0000019884822
CES3 / Q6UWW8 / carboxylesterase 3ENSG0000017282821
CES4A / Q5XG92 / carboxylesterase 4AENSG0000017282418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030025  Neuroligin 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion TAS
 biological_processGO:0007612 learning IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0050804 modulation of chemical synaptic transmission IBA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0071625 vocalization behavior IMP
 biological_processGO:0097104 postsynaptic membrane assembly IBA
 biological_processGO:0097105 presynaptic membrane assembly IBA
 biological_processGO:0099054 presynapse assembly TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0089717 spanning component of membrane TAS
 cellular_componentGO:0098983 symmetric, GABA-ergic, inhibitory synapse TAS
 cellular_componentGO:0098985 asymmetric, glutamatergic, excitatory synapse TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding TAS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165246 NLGN4Y / Q8NFZ3 / neuroligin 4, Y-linked  / complex






 

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