ENSG00000198848


Homo sapiens

Features
Gene ID: ENSG00000198848
  
Biological name :CES1
  
Synonyms : carboxylesterase 1 / CES1 / P23141
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q12.2
Gene start: 55802851
Gene end: 55833337
  
Corresponding Affymetrix probe sets: 209616_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456865
Ensembl peptide - ENSP00000455902
Ensembl peptide - ENSP00000455959
Ensembl peptide - ENSP00000353720
Ensembl peptide - ENSP00000355193
Ensembl peptide - ENSP00000390492
NCBI entrez gene - 1066     See in Manteia.
OMIM - 114835
RefSeq - XM_005255774
RefSeq - NM_001025194
RefSeq - NM_001025195
RefSeq - NM_001266
RefSeq Peptide - NP_001020366
RefSeq Peptide - NP_001020365
RefSeq Peptide - NP_001257
swissprot - P23141
swissprot - H3BQV8
swissprot - H3BQR4
swissprot - H3BSU0
Ensembl - ENSG00000198848
  
Related genetic diseases (OMIM): 114835 - Carboxylesterase 1 deficiency
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ces2ENSDARG00000041569Danio rerio
 ces3ENSDARG00000041595Danio rerio
 si:ch211-93f2.1ENSDARG00000104818Danio rerio
 si:ch211-93f2.1ENSDARG00000101726Danio rerio
 ENSGALG00000034990Gallus gallus
 ENSGALG00000040558Gallus gallus
 Ces1aENSMUSG00000071047Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CES2 / O00748 / carboxylesterase 2ENSG0000017283146
CES3 / Q6UWW8 / carboxylesterase 3ENSG0000017282843
CES5A / Q6NT32 / carboxylesterase 5AENSG0000015939842
NLGN3 / Q9NZ94 / neuroligin 3ENSG0000019633834
CES4A / Q5XG92 / carboxylesterase 4AENSG0000017282434
NLGN2 / Q8NFZ4 / neuroligin 2ENSG0000016999232
BCHE / P06276 / butyrylcholinesteraseENSG0000011420032
NLGN4X / Q8N0W4 / neuroligin 4, X-linkedENSG0000014693832
NLGN4Y / Q8NFZ3 / neuroligin 4, Y-linkedENSG0000016524632
NLGN1 / Q8N2Q7 / neuroligin 1ENSG0000016976031
ACHE / P22303 / acetylcholinesterase (Cartwright blood group)ENSG0000008708531
CEL / carboxyl ester lipaseENSG0000017083530


Protein motifs (from Interpro)
Interpro ID Name
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR019826  Carboxylesterase type B, active site
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006695 cholesterol biosynthetic process IDA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0009636 response to toxic substance TAS
 biological_processGO:0030855 epithelial cell differentiation IDA
 biological_processGO:0051791 medium-chain fatty acid metabolic process IDA
 biological_processGO:0090122 cholesterol ester hydrolysis involved in cholesterol transport TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004771 sterol esterase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047374 methylumbelliferyl-acetate deacetylase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity TAS


Pathways (from Reactome)
Pathway description
Phase I - Functionalization of compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198848 CES1 / P23141 / carboxylesterase 1  / complex






 

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