ENSG00000169992


Homo sapiens

Features
Gene ID: ENSG00000169992
  
Biological name :NLGN2
  
Synonyms : neuroligin 2 / NLGN2 / Q8NFZ4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7404874
Gene end: 7419860
  
Corresponding Affymetrix probe sets: 1554428_s_at (Human Genome U133 Plus 2.0 Array)   226288_s_at (Human Genome U133 Plus 2.0 Array)   235838_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305288
Ensembl peptide - ENSP00000461092
Ensembl peptide - ENSP00000461168
NCBI entrez gene - 57555     See in Manteia.
OMIM - 606479
RefSeq - XM_017024897
RefSeq - NM_020795
RefSeq - XM_005256744
RefSeq Peptide - NP_065846
swissprot - Q8NFZ4
swissprot - I3L498
Ensembl - ENSG00000169992
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn2aENSDARG00000077329Danio rerio
 nlgn2bENSDARG00000079251Danio rerio
 Nlgn2ENSMUSG00000051790Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLGN3 / Q9NZ94 / neuroligin 3ENSG0000019633864
NLGN1 / Q8N2Q7 / neuroligin 1ENSG0000016976063
NLGN4X / Q8N0W4 / neuroligin 4, X-linkedENSG0000014693862
NLGN4Y / Q8NFZ3 / neuroligin 4, Y-linkedENSG0000016524661
BCHE / P06276 / butyrylcholinesteraseENSG0000011420024
ACHE / P22303 / acetylcholinesterase (Cartwright blood group)ENSG0000008708524
CEL / carboxyl ester lipaseENSG0000017083524
CES5A / Q6NT32 / carboxylesterase 5AENSG0000015939823
CES2 / O00748 / carboxylesterase 2ENSG0000017283123
CES1 / P23141 / carboxylesterase 1ENSG0000019884822
CES3 / Q6UWW8 / carboxylesterase 3ENSG0000017282822
CES4A / Q5XG92 / carboxylesterase 4AENSG0000017282417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030023  Neuroligin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion IBA
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035418 protein localization to synapse IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0045217 cell-cell junction maintenance NAS
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0072553 terminal button organization ISS
 biological_processGO:0097104 postsynaptic membrane assembly IEA
 biological_processGO:0097105 presynaptic membrane assembly IEA
 biological_processGO:0097116 gephyrin clustering involved in postsynaptic density assembly IEA
 biological_processGO:0097119 postsynaptic density protein 95 clustering IEA
 biological_processGO:0097151 positive regulation of inhibitory postsynaptic potential IEA
 biological_processGO:0098609 cell-cell adhesion NAS
 biological_processGO:0099054 presynapse assembly TAS
 biological_processGO:1902474 positive regulation of protein localization to synapse IDA
 biological_processGO:1904862 inhibitory synapse assembly IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0045211 postsynaptic membrane NAS
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0089717 spanning component of membrane TAS
 cellular_componentGO:0098983 symmetric, GABA-ergic, inhibitory synapse TAS
 cellular_componentGO:0099055 integral component of postsynaptic membrane ISS
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169992 NLGN2 / Q8NFZ4 / neuroligin 2  / complex






 

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