ENSG00000196338


Homo sapiens

Features
Gene ID: ENSG00000196338
  
Biological name :NLGN3
  
Synonyms : neuroligin 3 / NLGN3 / Q9NZ94
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q13.1
Gene start: 71144831
Gene end: 71171201
  
Corresponding Affymetrix probe sets: 219726_at (Human Genome U133 Plus 2.0 Array)   234751_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479877
Ensembl peptide - ENSP00000363163
Ensembl peptide - ENSP00000379196
Ensembl peptide - ENSP00000445298
Ensembl peptide - ENSP00000351591
NCBI entrez gene - 54413     See in Manteia.
OMIM - 300336
RefSeq - XM_017029597
RefSeq - NM_001166660
RefSeq - NM_001321276
RefSeq - NM_018977
RefSeq - NM_181303
RefSeq - XM_006724662
RefSeq - XM_006724663
RefSeq - XM_011530974
RefSeq Peptide - NP_061850
RefSeq Peptide - NP_851820
RefSeq Peptide - NP_001160132
RefSeq Peptide - NP_001308205
swissprot - X5D2P6
swissprot - X5D7L6
swissprot - X5DNV3
swissprot - A0A087WW27
swissprot - Q9NZ94
swissprot - E7EVK0
Ensembl - ENSG00000196338
  
Related genetic diseases (OMIM): 300425 - {Autism susceptibility, X-linked 1}, 300425
  300494 - {Asperger syndrome susceptibility, X-linked 1}, 300494
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn3aENSDARG00000104786Danio rerio
 nlgn3bENSDARG00000062376Danio rerio
 NLGN3ENSGALG00000005553Gallus gallus
 Nlgn3ENSMUSG00000031302Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLGN4Y / Q8NFZ3 / neuroligin 4, Y-linkedENSG0000016524670
NLGN4X / Q8N0W4 / neuroligin 4, X-linkedENSG0000014693870
NLGN1 / Q8N2Q7 / neuroligin 1ENSG0000016976066
NLGN2 / Q8NFZ4 / neuroligin 2ENSG0000016999263
CEL / carboxyl ester lipaseENSG0000017083525
ACHE / P22303 / acetylcholinesterase (Cartwright blood group)ENSG0000008708525
BCHE / P06276 / butyrylcholinesteraseENSG0000011420025
CES1 / P23141 / carboxylesterase 1ENSG0000019884823
CES3 / Q6UWW8 / carboxylesterase 3ENSG0000017282822
CES2 / O00748 / carboxylesterase 2ENSG0000017283122
CES5A / Q6NT32 / carboxylesterase 5AENSG0000015939821
CES4A / Q5XG92 / carboxylesterase 4AENSG0000017282417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030024  Neuroligin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process ISS
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion IBA
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0007612 learning IMP
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048675 axon extension ISS
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060024 rhythmic synaptic transmission ISS
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060080 inhibitory postsynaptic potential ISS
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071625 vocalization behavior IMP
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IEA
 biological_processGO:0097104 postsynaptic membrane assembly IBA
 biological_processGO:0097105 presynaptic membrane assembly IBA
 biological_processGO:0099054 presynapse assembly TAS
 biological_processGO:1900271 regulation of long-term synaptic potentiation IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IEA
 biological_processGO:2000331 regulation of terminal button organization IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IEA
 biological_processGO:2000969 positive regulation of AMPA receptor activity ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0060076 excitatory synapse IDA
 cellular_componentGO:0089717 spanning component of membrane TAS
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098983 symmetric, GABA-ergic, inhibitory synapse TAS
 cellular_componentGO:0098985 asymmetric, glutamatergic, excitatory synapse TAS
 cellular_componentGO:0099055 integral component of postsynaptic membrane ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding ISS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196338 NLGN3 / Q9NZ94 / neuroligin 3  / complex






 

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