ENSMUSG00000031302


Mus musculus

Features
Gene ID: ENSMUSG00000031302
  
Biological name :Nlgn3
  
Synonyms : Neuroligin-3 / Nlgn3 / Q8BYM5
  
Possible biological names infered from orthology : Q9NZ94
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 101299168
Gene end: 101325963
  
Corresponding Affymetrix probe sets: 10601152 (MoGene1.0st)   1436135_at (Mouse Genome 430 2.0 Array)   1453756_at (Mouse Genome 430 2.0 Array)   1456384_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066304
Ensembl peptide - ENSMUSP00000123283
Ensembl peptide - ENSMUSP00000122213
Ensembl peptide - ENSMUSP00000113863
NCBI entrez gene - 245537     See in Manteia.
MGI - MGI:2444609
RefSeq - NM_172932
RefSeq Peptide - NP_766520
swissprot - A2AGI2
swissprot - A2AGI0
swissprot - A2AGI3
swissprot - Q8BYM5
Ensembl - ENSMUSG00000031302
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn3aENSDARG00000104786Danio rerio
 nlgn3bENSDARG00000062376Danio rerio
 NLGN3ENSGALG00000005553Gallus gallus
 NLGN3ENSG00000196338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*ENSMUSG0000006388770
Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*ENSMUSG0000005179065
Ache / P21836 / acetylcholinesterase / P22303* / acetylcholinesterase (Cartwright blood group)*ENSMUSG0000002332826
Bche / Q03311 / Cholinesterase / P06276* / butyrylcholinesterase*ENSMUSG0000002779224
Cel / Q64285 / Bile salt-activated lipase / carboxyl ester lipase*ENSMUSG0000002681824
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187723
Ces1e / Q64176 / Carboxylesterase 1E ENSMUSG0000006195923
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056023
Ces1b / carboxylesterase 1BENSMUSG0000007896423
Ces2h / carboxylesterase 2H / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000009181323
Ces1d / Q8VCT4 / Carboxylesterase 1D ENSMUSG0000005697322
Ces1a / carboxylesterase 1A / CES1* / P23141* / carboxylesterase 1*ENSMUSG0000007104722
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573022
Ces2f / carboxylesterase 2F / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006282622
Ces1h / carboxylesterase 1HENSMUSG0000007415622
Ces2b / carboxyesterase 2B / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005009722
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188622
Ces3b / Q8VCU1 / Carboxylesterase 3B / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006218122
Ces1f / Q91WU0 / Carboxylesterase 1F ENSMUSG0000003172522
Ces3a / Q63880 / Carboxylesterase 3A / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006992222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030024  Neuroligin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IGI
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion IBA
 biological_processGO:0007612 learning IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048675 axon extension ISS
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IGI
 biological_processGO:0050808 synapse organization ISO
 biological_processGO:0051965 positive regulation of synapse assembly IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060024 rhythmic synaptic transmission ISS
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060080 inhibitory postsynaptic potential IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IMP
 biological_processGO:0071625 vocalization behavior IEA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IMP
 biological_processGO:0097104 postsynaptic membrane assembly IMP
 biological_processGO:0097105 presynaptic membrane assembly IBA
 biological_processGO:1900271 regulation of long-term synaptic potentiation IMP
 biological_processGO:2000310 regulation of NMDA receptor activity IMP
 biological_processGO:2000311 regulation of AMPA receptor activity IMP
 biological_processGO:2000331 regulation of terminal button organization IMP
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IMP
 biological_processGO:2000969 positive regulation of AMPA receptor activity IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0099055 integral component of postsynaptic membrane ISS
 molecular_functionGO:0042043 neurexin family protein binding IBA
 molecular_functionGO:0050839 cell adhesion molecule binding ISS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

Allelic Composition: Nlgn3tm2.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Nlgn3tm4.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Nlgn3tm2.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Nlgn3tm2.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm1Sud/Y,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002068 abnormal parental behavior "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn2tm1Bros/Nlgn2tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thratm1Ffla/Thra+,Tg(Sycp1-cre)4Min/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004997 increased CNS synapse formation "greater frequency of the process of generating the initial connections between an axon and effector tissue or neuron " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn3tm2.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm1Sud/Y,Tg(Drd1-tdTomato)5Calak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011269 increased excitatory postsynaptic current amplitude "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Nlgn3tm1Rhn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0012314 enhanced learning "enhanced ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]
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Allelic Composition: Nlgn3tm2.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlgn3tm4.1Sud/Y,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Nlgn3tm1Sud/Y,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Nlgn3tm4.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

Allelic Composition: Nlgn3tm1.1Htz/Y
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000026383 Q8BGS1 / Epb41l5 / Band 4.1-like protein 5 / Q9HCM4* / erythrocyte membrane protein band 4.1 like 5*  / reaction / complex
 ENSMUSG00000024044 Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*  / reaction / complex
 ENSMUSG00000028906 Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*  / reaction / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / complex / reaction
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000019978 O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*  / complex / reaction
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex






 

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