ENSMUSG00000037541


Mus musculus

Features
Gene ID: ENSMUSG00000037541
  
Biological name :Shank2
  
Synonyms : Q80Z38 / SH3 and multiple ankyrin repeat domains protein 2 / Shank2
  
Possible biological names infered from orthology : Q9UPX8 / SH3 and multiple ankyrin repeat domains 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F5
Gene start: 144001928
Gene end: 144424494
  
Corresponding Affymetrix probe sets: 10559333 (MoGene1.0st)   10559341 (MoGene1.0st)   10559343 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000149134
Ensembl peptide - ENSMUSP00000101520
Ensembl peptide - ENSMUSP00000101522
Ensembl peptide - ENSMUSP00000146440
Ensembl peptide - ENSMUSP00000095542
NCBI entrez gene - 210274     See in Manteia.
MGI - MGI:2671987
RefSeq - XM_017322093
RefSeq - XM_006508533
RefSeq - XM_006508534
RefSeq - XM_006508535
RefSeq - XM_006508536
RefSeq - XM_017322091
RefSeq - XM_017322092
RefSeq - NM_001081370
RefSeq - NM_001113373
RefSeq - XM_006508519
RefSeq - XM_006508520
RefSeq - XM_006508521
RefSeq - XM_006508522
RefSeq - XM_006508523
RefSeq - XM_006508524
RefSeq - XM_006508525
RefSeq - XM_006508526
RefSeq - XM_006508527
RefSeq - XM_006508528
RefSeq - XM_006508529
RefSeq - XM_006508530
RefSeq - XM_006508531
RefSeq - XM_006508532
RefSeq Peptide - NP_001074839
RefSeq Peptide - NP_001106844
swissprot - D3Z5K8
swissprot - A0A1L1SQP7
swissprot - Q80Z38
swissprot - A0A1C7ZMY3
Ensembl - ENSMUSG00000037541
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shank2ENSDARG00000062325Danio rerio
 ENSGALG00000035916Gallus gallus
 ENSGALG00000038779Gallus gallus
 Q9UPX8ENSG00000162105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4ACU6 / Shank3 / SH3 and multiple ankyrin repeat domains protein 3 / SH3 and multiple ankyrin repeat domains 3*ENSMUSG0000002262340
D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*ENSMUSG0000003873840


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR032425  Talin, N-terminal F0 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0071625 vocalization behavior IMP
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005883 neurofilament IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IDA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031526 brush border membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0048786 presynaptic active zone ISO
 cellular_componentGO:0060170 ciliary membrane ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1.1Tmb/Shank2+
Genetic Background: B6.129-Shank2tm1.1Tmb

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

Allelic Composition: Shank2tm1.1Bcgen/Shank2tm1.1Bcgen,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1.1Tmb/Shank2+
Genetic Background: B6.129-Shank2tm1.1Tmb

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

Allelic Composition: Shank2tm1Mgle/Shank2+
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

Allelic Composition: Shank2tm1.1Bcgen/Shank2tm1.1Bcgen,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1.1Bcgen/Shank2tm1.1Bcgen,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0002863 improved righting response "faster ability or less amount of time needed to recover from supine position" [J:86936]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1.1Tmb/Shank2+
Genetic Background: B6.129-Shank2tm1.1Tmb

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

Allelic Composition: Shank2tm1.1Bcgen/Shank2tm1.1Bcgen,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Shank2tm1.1Tmb/Shank2+
Genetic Background: B6.129-Shank2tm1.1Tmb

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

 MP:0020357 abnormal excitatory synapse morphology "any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]
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Allelic Composition: Shank2tm1Mgle/Shank2tm1Mgle
Genetic Background: B6.129S4-Shank2tm1Mgle

Allelic Composition: Shank2tm1.1Bcgen/Shank2tm1.1Bcgen,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / complex / reaction
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / complex
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex






 

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