ENSMUSG00000020476


Mus musculus

Features
Gene ID: ENSMUSG00000020476
  
Biological name :Dbnl
  
Synonyms : Dbnl / Drebrin-like protein / Q62418
  
Possible biological names infered from orthology : drebrin like / Q9UJU6
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 5788488
Gene end: 5800962
  
Corresponding Affymetrix probe sets: 10374068 (MoGene1.0st)   1460334_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020769
Ensembl peptide - ENSMUSP00000099992
Ensembl peptide - ENSMUSP00000105471
NCBI entrez gene - 13169     See in Manteia.
MGI - MGI:700006
RefSeq - NM_001146309
RefSeq - NM_001146308
RefSeq - NM_013810
RefSeq Peptide - NP_001139780
RefSeq Peptide - NP_001139781
RefSeq Peptide - NP_038838
swissprot - Q62418
Ensembl - ENSMUSG00000020476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbnlaENSDARG00000008170Danio rerio
 dbnlbENSDARG00000016016Danio rerio
 DBNLENSG00000136279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dbn1 / Q9QXS6 / Drebrin / Q16643* / drebrin 1*ENSMUSG0000003467533
Cttn / Q60598 / cortactin / Q14247*ENSMUSG0000003107822
Hcls1 / P49710 / Hematopoietic lineage cell-specific protein / P14317* / hematopoietic cell-specific Lyn substrate 1*ENSMUSG0000002283121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002108  Actin-depolymerising factor homology domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR029923  Drebrin-like protein
 IPR035717  Drebrin-like protein, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0071800 podosome assembly IMP
 biological_processGO:0097178 ruffle assembly IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Neurexins and neuroligins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

Allelic Composition: Dbnltm1Jwnd/Dbnl+
Genetic Background: involves: BALB/c

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013807 generalized edema "generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body" [HP:0007430, HPO:curators]
Show

Allelic Composition: Gpc3tm1Arge/Y,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / reaction / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / reaction / complex
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / reaction / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex / reaction
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / reaction / complex
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex / reaction
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex / reaction
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex / reaction
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex / reaction
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / reaction / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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