ENSMUSG00000031078


Mus musculus

Features
Gene ID: ENSMUSG00000031078
  
Biological name :Cttn
  
Synonyms : cortactin / Cttn / Q60598
  
Possible biological names infered from orthology : Q14247
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 144435733
Gene end: 144471009
  
Corresponding Affymetrix probe sets: 10569569 (MoGene1.0st)   1421313_s_at (Mouse Genome 430 2.0 Array)   1421314_at (Mouse Genome 430 2.0 Array)   1421315_s_at (Mouse Genome 430 2.0 Array)   1423917_a_at (Mouse Genome 430 2.0 Array)   1433908_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033407
Ensembl peptide - ENSMUSP00000099368
NCBI entrez gene - 13043     See in Manteia.
MGI - MGI:99695
RefSeq - XM_006508475
RefSeq - NM_001252572
RefSeq - NM_007803
RefSeq - XM_006508473
RefSeq - XM_006508474
RefSeq Peptide - NP_001239501
RefSeq Peptide - NP_031829
swissprot - Q921L6
swissprot - Q60598
Ensembl - ENSMUSG00000031078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cttnENSDARG00000011777Danio rerio
 CTTNENSGALG00000007700Gallus gallus
 CTTNENSG00000085733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcls1 / P49710 / Hematopoietic lineage cell-specific protein / P14317* / hematopoietic cell-specific Lyn substrate 1*ENSMUSG0000002283142
Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*ENSMUSG0000002047618
Dbn1 / Q9QXS6 / Drebrin / Q16643* / drebrin 1*ENSMUSG0000003467512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003134  Hs1/Cortactin
 IPR015503  Cortactin
 IPR035716  Cortactin, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IGI
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030516 regulation of axon extension ISS
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization ISS
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0048041 focal adhesion assembly ISS
 biological_processGO:0048812 neuron projection morphogenesis ISS
 biological_processGO:0048870 cell motility ISS
 biological_processGO:0097062 dendritic spine maintenance IGI
 biological_processGO:0097581 lamellipodium organization ISS
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit ISS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction ISS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:1990023 mitotic spindle midzone IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002210 abnormal sex determination "anomaly of primary or secondary sexual development or characteristics" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0011131 abnormal lung endothelial cell physiology "any functional anomaly of the squamous cells forming the lining of the pulmonary vasculature" [MGI:csmith]
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Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0012738 abnormal secondary polar body morphology "any structural anomaly of the small cell formed by the second meiotic division of oocytes; in mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell" [MGI:anna]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction






 

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